| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | GAB1 | Tyr589 | SHDSEENyVPMNPNL | phosphorylation up-regulates activity | 10978177 | SIGNOR-251315 |
| MET | GAB1 | Tyr589 | SHDSEENyVPMNPNL | phosphorylation up-regulates activity | 10734310 | SIGNOR-250288 |
| EGFR | GAB1 | Tyr589 | SHDSEENyVPMNPNL | phosphorylation up-regulates activity | 9890893 | SIGNOR-236416 |
| PTPN11 | GAB1 | Tyr589 | SHDSEENyVPMNPNL | dephosphorylation down-regulates activity | 10068651 | SIGNOR-236258 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | phosphorylation up-regulates → | GAB1 PTyr589 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251315 |
| MET | phosphorylation up-regulates → | GAB1 PTyr589 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250288 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr589 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236416 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr589 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236258 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251315 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250288 |
| EGFR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236416 |
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-236258 |
