| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | dephosphorylation down-regulates activity | 11323411 | SIGNOR-248674 |
| EGFR | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates | 9890893 | SIGNOR-236392 |
| SRC | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates activity | 19881549 | SIGNOR-236302 |
| MET | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates activity | 10734310 | SIGNOR-250289 |
| INSR | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates activity | 10978177 | SIGNOR-251316 |
| PTPN11 | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | dephosphorylation down-regulates | 10068651 | SIGNOR-236262 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr627 | dephosphorylation up-regulates → | GAB1 | 11323411 | SIGNOR-248674 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236392 |
| SRC | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 19881549 | SIGNOR-236302 |
| MET | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250289 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251316 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr627 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236262 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-248674 |
| EGFR | phosphorylation → up-regulates | GAB1 | SIGNOR-236392 |
| SRC | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236302 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250289 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251316 |
| PTPN11 | dephosphorylation down-regulates | GAB1 | SIGNOR-236262 |
