| Name | SMAD4 |
| ID | Q13485 |
| Role | substrate |
| Enzymatic Domains |
MH1 18-142 PROSITE-ProRule
MH2 323-552 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SMAD9 | SMAD4 | – | phosphorylation up-regulates | 20957627 | SIGNOR-168740 | |
| ERK1/2 | SMAD4 | Thr277 | GSRTAPYtPNLPHHQ | phosphorylation up-regulates | 12801888 | SIGNOR-244739 |
| GSK3B | SMAD4 | Thr265 | ATYHHNStTTWTGSR | phosphorylation down-regulates quantity by destabilization | 25373906 | SIGNOR-276442 |
| SMAD5 | SMAD4 | – | phosphorylation up-regulates | 20957627 | SIGNOR-168737 | |
| PLK1 | SMAD4 | Thr197 | ASTETYStPALLAPS | phosphorylation down-regulates quantity by destabilization | 35437307 | SIGNOR-277591 |
| STK11 | SMAD4 | Thr77 | KCVTIQRtLDGRLQV | phosphorylation down-regulates activity | 20974850 | SIGNOR-278193 |
| GSK3B | SMAD4 | Thr273 | TTWTGSRtAPYTPNL | phosphorylation down-regulates quantity by destabilization | 25373906 | SIGNOR-276440 |
| MAPK3 | SMAD4 | Thr277 | GSRTAPYtPNLPHHQ | phosphorylation up-regulates | 12801888 | SIGNOR-101664 |
| MAPK1 | SMAD4 | Thr277 | GSRTAPYtPNLPHHQ | phosphorylation up-regulates | 12801888 | SIGNOR-101660 |
| Gbeta | SMAD4 | – | phosphorylation up-regulates | 12801888 | SIGNOR-270107 | |
| SMAD1 | SMAD4 | – | phosphorylation up-regulates | 20957627 | SIGNOR-168734 | |
| GSK3B | SMAD4 | Thr269 | HNSTTTWtGSRTAPY | phosphorylation down-regulates quantity by destabilization | 25373906 | SIGNOR-276441 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | SMAD4 PThr277 | phosphorylation up-regulates → | SMAD4 | 12801888 | SIGNOR-244739 |
| GSK3B | phosphorylation up-regulates → | SMAD4 PThr265 | phosphorylation down-regulates ⊣ | SMAD4 | 25373906 | SIGNOR-276442 |
| PLK1 | phosphorylation up-regulates → | SMAD4 PThr197 | phosphorylation down-regulates ⊣ | SMAD4 | 35437307 | SIGNOR-277591 |
| STK11 | phosphorylation up-regulates → | SMAD4 PThr77 | phosphorylation down-regulates ⊣ | SMAD4 | 20974850 | SIGNOR-278193 |
| GSK3B | phosphorylation up-regulates → | SMAD4 PThr273 | phosphorylation down-regulates ⊣ | SMAD4 | 25373906 | SIGNOR-276440 |
| MAPK3 | phosphorylation up-regulates → | SMAD4 PThr277 | phosphorylation up-regulates → | SMAD4 | 12801888 | SIGNOR-101664 |
| MAPK1 | phosphorylation up-regulates → | SMAD4 PThr277 | phosphorylation up-regulates → | SMAD4 | 12801888 | SIGNOR-101660 |
| GSK3B | phosphorylation up-regulates → | SMAD4 PThr269 | phosphorylation down-regulates ⊣ | SMAD4 | 25373906 | SIGNOR-276441 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SMAD9 | phosphorylation → up-regulates | SMAD4 | SIGNOR-168740 |
| ERK1/2 | phosphorylation → up-regulates | SMAD4 | SIGNOR-244739 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | SMAD4 | SIGNOR-276442 |
| SMAD5 | phosphorylation → up-regulates | SMAD4 | SIGNOR-168737 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | SMAD4 | SIGNOR-277591 |
| STK11 | phosphorylation → down-regulates activity | SMAD4 | SIGNOR-278193 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | SMAD4 | SIGNOR-276440 |
| MAPK3 | phosphorylation → up-regulates | SMAD4 | SIGNOR-101664 |
| MAPK1 | phosphorylation → up-regulates | SMAD4 | SIGNOR-101660 |
| Gbeta | phosphorylation → up-regulates | SMAD4 | SIGNOR-270107 |
| SMAD1 | phosphorylation → up-regulates | SMAD4 | SIGNOR-168734 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | SMAD4 | SIGNOR-276441 |