| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | SMAD4 | Thr269 | HNSTTTWtGSRTAPY | phosphorylation down-regulates quantity by destabilization | 25373906 | SIGNOR-276441 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | SMAD4 PThr269 | phosphorylation down-regulates ⊣ | SMAD4 | 25373906 | SIGNOR-276441 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation![]() down-regulates quantity by destabilization | SMAD4 | SIGNOR-276441 |