| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | SMAD4 | Thr197 | ASTETYStPALLAPS | phosphorylation down-regulates quantity by destabilization | 35437307 | SIGNOR-277591 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | SMAD4 PThr197 | phosphorylation down-regulates ⊣ | SMAD4 | 35437307 | SIGNOR-277591 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation![]() down-regulates quantity by destabilization | SMAD4 | SIGNOR-277591 |