| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | SQSTM1 | Ser403 | ESLSQMLsMGFSDEG | phosphorylation down-regulates quantity by destabilization | 25040165 | SIGNOR-278349 |
| TBK1 | SQSTM1 | Ser403 | ESLSQMLsMGFSDEG | phosphorylation up-regulates | 22921120 | SIGNOR-191944 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | phosphorylation up-regulates → | SQSTM1 PSer403 | phosphorylation down-regulates ⊣ | SQSTM1 | 25040165 | SIGNOR-278349 |
| TBK1 | phosphorylation up-regulates → | SQSTM1 PSer403 | phosphorylation up-regulates → | SQSTM1 | 22921120 | SIGNOR-191944 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ULK1 | phosphorylation down-regulates quantity by destabilization | SQSTM1 | SIGNOR-278349 |
| TBK1 | phosphorylation → up-regulates | SQSTM1 | SIGNOR-191944 |
