| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG1 | TRPC3 | Ser251 | KNDYRKLsMQCKDFV | phosphorylation down-regulates | 14983059 | SIGNOR-122978 |
| PRKG1 | TRPC3 | Ser251 | KNDYRKLsMQCKDFV | phosphorylation down-regulates | 16331690 | SIGNOR-142961 |
| PRKG1 | TRPC3 | Ser251 | KNDYRKLsMQCKDFV | phosphorylation down-regulates | 16331690 | SIGNOR-142953 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG1 | phosphorylation up-regulates → | TRPC3 PSer251 | phosphorylation down-regulates ⊣ | TRPC3 | 14983059 | SIGNOR-122978 |
| PRKG1 | phosphorylation up-regulates → | TRPC3 PSer251 | phosphorylation down-regulates ⊣ | TRPC3 | 16331690 | SIGNOR-142961 |
| PRKG1 | phosphorylation up-regulates → | TRPC3 PSer251 | phosphorylation down-regulates ⊣ | TRPC3 | 16331690 | SIGNOR-142953 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKG1 | phosphorylation down-regulates | TRPC3 | SIGNOR-122978 |
| PRKG1 | phosphorylation down-regulates | TRPC3 | SIGNOR-142961 |
| PRKG1 | phosphorylation down-regulates | TRPC3 | SIGNOR-142953 |
