| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CB | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248379 |
| PPP2CB | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248602 |
| CDK5 | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | phosphorylation unknown | 11278334 | SIGNOR-249194 |
| Calcineurin | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-252334 |
| PPP3CC | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248524 |
| PPP2CA | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248645 |
| PPP3CA | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248693 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CB | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248379 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248602 |
| CDK5 | phosphorylation up-regulates → | PPP1R1A PSer67 | phosphorylation down-regulates ⊣ | PPP1R1A | 11278334 | SIGNOR-249194 |
| Calcineurin | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-252334 |
| PPP3CC | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248524 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248645 |
| PPP3CA | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248693 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP3CB | dephosphorylation → unknown | PPP1R1A | SIGNOR-248379 |
| PPP2CB | dephosphorylation → unknown | PPP1R1A | SIGNOR-248602 |
| CDK5 | phosphorylation → unknown | PPP1R1A | SIGNOR-249194 |
| Calcineurin | dephosphorylation → unknown | PPP1R1A | SIGNOR-252334 |
| PPP3CC | dephosphorylation → unknown | PPP1R1A | SIGNOR-248524 |
| PPP2CA | dephosphorylation → unknown | PPP1R1A | SIGNOR-248645 |
| PPP3CA | dephosphorylation → unknown | PPP1R1A | SIGNOR-248693 |
