| Name | PIN1 |
| ID | Q13526 |
| Role | substrate |
| Enzymatic Domains |
WW 5-39 PROSITE-ProRule
PpiC 52-163 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | PIN1 | Ser16 | PGWEKRMsRSSGRVY | phosphorylation down-regulates activity | 11723108 | SIGNOR-112164 |
| PLK1 | PIN1 | Ser65 | SHLLVKHsQSRRPSS | phosphorylation up-regulates | 16118204 | SIGNOR-139919 |
| DAPK1 | PIN1 | Ser71 | HSQSRRPsSWRQEKI | phosphorylation down-regulates activity | 21497122 | SIGNOR-278160 |
| AURKA | PIN1 | Ser16 | PGWEKRMsRSSGRVY | phosphorylation down-regulates activity | 23970419 | SIGNOR-202487 |
| MAP3K11 | PIN1 | Ser138 | QKPFEDAsFALRTGE | phosphorylation up-regulates | 25519816 | SIGNOR-205586 |
| MAPK8 | PIN1 | Ser115 | SQFSDCSsAKARGDL | phosphorylation up-regulates quantity by stabilization | 34048060 | SIGNOR-277562 |
| MAPK9 | PIN1 | Ser115 | SQFSDCSsAKARGDL | phosphorylation up-regulates quantity by stabilization | 34048060 | SIGNOR-277563 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | PIN1 PSer16 | phosphorylation down-regulates ⊣ | PIN1 | 11723108 | SIGNOR-112164 |
| PLK1 | phosphorylation up-regulates → | PIN1 PSer65 | phosphorylation up-regulates → | PIN1 | 16118204 | SIGNOR-139919 |
| DAPK1 | phosphorylation up-regulates → | PIN1 PSer71 | phosphorylation down-regulates ⊣ | PIN1 | 21497122 | SIGNOR-278160 |
| AURKA | phosphorylation up-regulates → | PIN1 PSer16 | phosphorylation down-regulates ⊣ | PIN1 | 23970419 | SIGNOR-202487 |
| MAP3K11 | phosphorylation up-regulates → | PIN1 PSer138 | phosphorylation up-regulates → | PIN1 | 25519816 | SIGNOR-205586 |
| MAPK8 | phosphorylation up-regulates → | PIN1 PSer115 | phosphorylation up-regulates → | PIN1 | 34048060 | SIGNOR-277562 |
| MAPK9 | phosphorylation up-regulates → | PIN1 PSer115 | phosphorylation up-regulates → | PIN1 | 34048060 | SIGNOR-277563 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | PIN1 | SIGNOR-112164 |
| PLK1 | phosphorylation → up-regulates | PIN1 | SIGNOR-139919 |
| DAPK1 | phosphorylation → down-regulates activity | PIN1 | SIGNOR-278160 |
| AURKA | phosphorylation → down-regulates activity | PIN1 | SIGNOR-202487 |
| MAP3K11 | phosphorylation → up-regulates | PIN1 | SIGNOR-205586 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | PIN1 | SIGNOR-277562 |
| MAPK9 | phosphorylation → up-regulates quantity by stabilization | PIN1 | SIGNOR-277563 |