| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | PIN1 | Ser16 | PGWEKRMsRSSGRVY | phosphorylation down-regulates activity | 11723108 | SIGNOR-112164 |
| AURKA | PIN1 | Ser16 | PGWEKRMsRSSGRVY | phosphorylation down-regulates activity | 23970419 | SIGNOR-202487 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | PIN1 PSer16 | phosphorylation down-regulates ⊣ | PIN1 | 11723108 | SIGNOR-112164 |
| AURKA | phosphorylation up-regulates → | PIN1 PSer16 | phosphorylation down-regulates ⊣ | PIN1 | 23970419 | SIGNOR-202487 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | PIN1 | SIGNOR-112164 |
| AURKA | phosphorylation → down-regulates activity | PIN1 | SIGNOR-202487 |