Entity Details

Name EIF4EBP1
ID Q13541
Role substrate
Enzymatic Domains
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MTOREIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
10942774SIGNOR-226714
MTOREIF4EBP1Thr36LPPGDYStTPGGTLFphosphorylation
down-regulates activity
9465032SIGNOR-55697
mTORC1EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
23486913SIGNOR-217114
GSK3BEIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
18701453SIGNOR-236660
MTOREIF4EBP1Ser83 PTIPGVTsPSSDEPPphosphorylation
down-regulates activity
9204908SIGNOR-250292
RPS6KA5EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
12213813SIGNOR-262991
MTOREIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
23486913SIGNOR-219266
CDK13EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
up-regulates activity
36882522SIGNOR-273113
mTORC1EIF4EBP1phosphorylation
down-regulates activity
12747827SIGNOR-236678
CSNK2A1EIF4EBP1Ser112 KRAGGEEsQFEMDIphosphorylation
down-regulates
12588975SIGNOR-98280
RPS6KA5EIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
11777913SIGNOR-249131
MTOREIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
12747827SIGNOR-101115
MAPK1EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
11691836SIGNOR-249390
MAPK14EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
11777913SIGNOR-250097
MAPK1EIF4EBP1Ser83 PTIPGVTsPSSDEPPphosphorylation
down-regulates activity
11691836SIGNOR-249391
MTOREIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
23486913SIGNOR-219262
RPS6KA5EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
12213813SIGNOR-262993
mTORC1EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
12747827SIGNOR-236698
MTOREIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
17510057SIGNOR-154814
mTORC1EIF4EBP1phosphorylation
down-regulates activity
17510057SIGNOR-235748
MTOREIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
10942774SIGNOR-80797
mTORC1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
12747827SIGNOR-235964
CSNK2A2EIF4EBP1Ser112 KRAGGEEsQFEMDIphosphorylation
down-regulates activity
9806882SIGNOR-249334
MTOREIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
20670887SIGNOR-167184
GSK3BEIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
18701453SIGNOR-236026
ATMEIF4EBP1Ser112 KRAGGEEsQFEMDIphosphorylation
down-regulates
11146653SIGNOR-85619
PIM2EIF4EBP1phosphorylation
up-regulates activity
19290049SIGNOR-279091
MAPK14EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
11777913SIGNOR-250098
mTORC1EIF4EBP1phosphorylation
down-regulates activity
20670887SIGNOR-235745
MTOREIF4EBP1Thr36LPPGDYStTPGGTLFphosphorylation
down-regulates activity
17510057SIGNOR-154810
MTOREIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
10942774SIGNOR-226710
MTOREIF4EBP1Thr36LPPGDYStTPGGTLFphosphorylation
down-regulates activity
20670887SIGNOR-167180
mTORC1EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
12747827SIGNOR-236690
MAPK1EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
11691836SIGNOR-249393
mTORC1EIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
9465032SIGNOR-217090
mTORC1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
23486913SIGNOR-217141
mTORC1EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
23486913SIGNOR-217110
MTOREIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
23486913SIGNOR-219257
MAPK1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
11691836SIGNOR-249394
mTORC1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
10942774SIGNOR-236702
mTORC1EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
23486913SIGNOR-217137
PRKCDEIF4EBP1phosphorylation
down-regulates activity
10698949SIGNOR-279100
RPS6KA5EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
12213813SIGNOR-262992
CSNK1EEIF4EBP1Thr50FSTTPGGtRIIYDRKphosphorylation
down-regulates
24247720SIGNOR-203276
MTOREIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
23486913SIGNOR-219273
CSNK1EEIF4EBP1Thr41 YSTTPGGtLFSTTPGphosphorylation
down-regulates
24247720SIGNOR-203240
MAPK1EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
11691836SIGNOR-249392
RPS6KA5EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
12213813SIGNOR-262994
MTOREIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
12747827SIGNOR-101127
MTOREIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
12747827SIGNOR-101119
CyclinK/CDK13EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
up-regulates activity
36882522SIGNOR-273114
MAPK1EIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates
11777913SIGNOR-113563
mTORC1EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
12747827SIGNOR-236694
MTOREIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
12747827SIGNOR-101123
mTORC1EIF4EBP1Thr36LPPGDYStTPGGTLFphosphorylation
down-regulates activity
9465032SIGNOR-217086
CDK1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
11553333SIGNOR-110416
MAPK14EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
11777913SIGNOR-250099
MTOREIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
9465032SIGNOR-55701
GSK3BEIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
23584478SIGNOR-201699
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MTORphosphorylation
up-regulates
EIF4EBP1
PSer65
phosphorylation
down-regulates
EIF4EBP110942774SIGNOR-226714
MTORphosphorylation
up-regulates
EIF4EBP1
PThr36
phosphorylation
down-regulates
EIF4EBP19465032SIGNOR-55697
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP123486913SIGNOR-217114
GSK3Bphosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP118701453SIGNOR-236660
MTORphosphorylation
up-regulates
EIF4EBP1
PSer83
phosphorylation
down-regulates
EIF4EBP19204908SIGNOR-250292
RPS6KA5phosphorylation
up-regulates
EIF4EBP1
PThr37
phosphorylation
down-regulates
EIF4EBP112213813SIGNOR-262991
MTORphosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP123486913SIGNOR-219266
CDK13phosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
up-regulates
EIF4EBP136882522SIGNOR-273113
CSNK2A1phosphorylation
up-regulates
EIF4EBP1
PSer112
phosphorylation
down-regulates
EIF4EBP112588975SIGNOR-98280
RPS6KA5phosphorylation
up-regulates
EIF4EBP1
PThr45
phosphorylation
down-regulates
EIF4EBP111777913SIGNOR-249131
MTORphosphorylation
up-regulates
EIF4EBP1
PSer65
phosphorylation
down-regulates
EIF4EBP112747827SIGNOR-101115
MAPK1phosphorylation
up-regulates
EIF4EBP1
PSer65
phosphorylation
down-regulates
EIF4EBP111691836SIGNOR-249390
MAPK14phosphorylation
up-regulates
EIF4EBP1
PSer65
phosphorylation
down-regulates
EIF4EBP111777913SIGNOR-250097
MAPK1phosphorylation
up-regulates
EIF4EBP1
PSer83
phosphorylation
down-regulates
EIF4EBP111691836SIGNOR-249391
MTORphosphorylation
up-regulates
EIF4EBP1
PThr37
phosphorylation
down-regulates
EIF4EBP123486913SIGNOR-219262
RPS6KA5phosphorylation
up-regulates
EIF4EBP1
PSer65
phosphorylation
down-regulates
EIF4EBP112213813SIGNOR-262993
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP112747827SIGNOR-236698
MTORphosphorylation
up-regulates
EIF4EBP1
PThr45
phosphorylation
down-regulates
EIF4EBP117510057SIGNOR-154814
MTORphosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP110942774SIGNOR-80797
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP112747827SIGNOR-235964
CSNK2A2phosphorylation
up-regulates
EIF4EBP1
PSer112
phosphorylation
down-regulates
EIF4EBP19806882SIGNOR-249334
MTORphosphorylation
up-regulates
EIF4EBP1
PThr45
phosphorylation
down-regulates
EIF4EBP120670887SIGNOR-167184
GSK3Bphosphorylation
up-regulates
EIF4EBP1
PThr37
phosphorylation
down-regulates
EIF4EBP118701453SIGNOR-236026
ATMphosphorylation
up-regulates
EIF4EBP1
PSer112
phosphorylation
down-regulates
EIF4EBP111146653SIGNOR-85619
MAPK14phosphorylation
up-regulates
EIF4EBP1
PThr37
phosphorylation
down-regulates
EIF4EBP111777913SIGNOR-250098
MTORphosphorylation
up-regulates
EIF4EBP1
PThr36
phosphorylation
down-regulates
EIF4EBP117510057SIGNOR-154810
MTORphosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP110942774SIGNOR-226710
MTORphosphorylation
up-regulates
EIF4EBP1
PThr36
phosphorylation
down-regulates
EIF4EBP120670887SIGNOR-167180
mTORC1phosphorylation
up-regulates
EIF4EBP1
PSer65
phosphorylation
down-regulates
EIF4EBP112747827SIGNOR-236690
MAPK1phosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP111691836SIGNOR-249393
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr45
phosphorylation
down-regulates
EIF4EBP19465032SIGNOR-217090
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP123486913SIGNOR-217141
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr37
phosphorylation
down-regulates
EIF4EBP123486913SIGNOR-217110
MTORphosphorylation
up-regulates
EIF4EBP1
PSer65
phosphorylation
down-regulates
EIF4EBP123486913SIGNOR-219257
MAPK1phosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP111691836SIGNOR-249394
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP110942774SIGNOR-236702
mTORC1phosphorylation
up-regulates
EIF4EBP1
PSer65
phosphorylation
down-regulates
EIF4EBP123486913SIGNOR-217137
RPS6KA5phosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP112213813SIGNOR-262992
CSNK1Ephosphorylation
up-regulates
EIF4EBP1
PThr50
phosphorylation
down-regulates
EIF4EBP124247720SIGNOR-203276
MTORphosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP123486913SIGNOR-219273
CSNK1Ephosphorylation
up-regulates
EIF4EBP1
PThr41
phosphorylation
down-regulates
EIF4EBP124247720SIGNOR-203240
MAPK1phosphorylation
up-regulates
EIF4EBP1
PThr37
phosphorylation
down-regulates
EIF4EBP111691836SIGNOR-249392
RPS6KA5phosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP112213813SIGNOR-262994
MTORphosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP112747827SIGNOR-101127
MTORphosphorylation
up-regulates
EIF4EBP1
PThr37
phosphorylation
down-regulates
EIF4EBP112747827SIGNOR-101119
CyclinK/CDK13phosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
up-regulates
EIF4EBP136882522SIGNOR-273114
MAPK1phosphorylation
up-regulates
EIF4EBP1
PThr45
phosphorylation
down-regulates
EIF4EBP111777913SIGNOR-113563
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr37
phosphorylation
down-regulates
EIF4EBP112747827SIGNOR-236694
MTORphosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP112747827SIGNOR-101123
mTORC1phosphorylation
up-regulates
EIF4EBP1
PThr36
phosphorylation
down-regulates
EIF4EBP19465032SIGNOR-217086
CDK1phosphorylation
up-regulates
EIF4EBP1
PThr70
phosphorylation
down-regulates
EIF4EBP111553333SIGNOR-110416
MAPK14phosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP111777913SIGNOR-250099
MTORphosphorylation
up-regulates
EIF4EBP1
PThr45
phosphorylation
down-regulates
EIF4EBP19465032SIGNOR-55701
GSK3Bphosphorylation
up-regulates
EIF4EBP1
PThr46
phosphorylation
down-regulates
EIF4EBP123584478SIGNOR-201699
Regulator Mechanism/Effect Target SIGNOR-ID
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-226714
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-55697
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-217114
GSK3Bphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-236660
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-250292
RPS6KA5phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-262991
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-219266
CDK13phosphorylation

up-regulates activity
EIF4EBP1SIGNOR-273113
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-236678
CSNK2A1phosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-98280
RPS6KA5phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-249131
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-101115
MAPK1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-249390
MAPK14phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-250097
MAPK1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-249391
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-219262
RPS6KA5phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-262993
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-236698
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-154814
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-235748
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-80797
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-235964
CSNK2A2phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-249334
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-167184
GSK3Bphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-236026
ATMphosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-85619
PIM2phosphorylation

up-regulates activity
EIF4EBP1SIGNOR-279091
MAPK14phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-250098
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-235745
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-154810
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-226710
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-167180
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-236690
MAPK1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-249393
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-217090
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-217141
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-217110
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-219257
MAPK1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-249394
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-236702
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-217137
PRKCDphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-279100
RPS6KA5phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-262992
CSNK1Ephosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-203276
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-219273
CSNK1Ephosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-203240
MAPK1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-249392
RPS6KA5phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-262994
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-101127
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-101119
CyclinK/CDK13phosphorylation

up-regulates activity
EIF4EBP1SIGNOR-273114
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-113563
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-236694
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-101123
mTORC1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-217086
CDK1phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-110416
MAPK14phosphorylation

down-regulates activity
EIF4EBP1SIGNOR-250099
MTORphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-55701
GSK3Bphosphorylation

down-regulates activity
EIF4EBP1SIGNOR-201699