Entity Details

Name EIF4EBP1
ID Q13541
Role substrate
Enzymatic Domains
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MTOREIF4EBP1Thr36LPPGDYStTPGGTLFphosphorylation
down-regulates activity
9465032SIGNOR-55697
mTORC1EIF4EBP1Thr36LPPGDYStTPGGTLFphosphorylation
down-regulates activity
9465032SIGNOR-217086
MAPK14EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
11777913SIGNOR-250099
RPS6KA5EIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
11777913SIGNOR-249131
CSNK2A1EIF4EBP1Ser112 KRAGGEEsQFEMDIphosphorylation
down-regulates
12588975SIGNOR-98280
GSK3BEIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
23584478SIGNOR-201699
MTOREIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
12747827SIGNOR-101115
MAPK1EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
11691836SIGNOR-249390
MTOREIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
10942774SIGNOR-80797
MAPK14EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
11777913SIGNOR-250097
GSK3BEIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
18701453SIGNOR-236026
ATMEIF4EBP1Ser112 KRAGGEEsQFEMDIphosphorylation
down-regulates
11146653SIGNOR-85619
MTOREIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
23486913SIGNOR-219262
MTOREIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
9465032SIGNOR-55701
MTOREIF4EBP1Thr36LPPGDYStTPGGTLFphosphorylation
down-regulates activity
17510057SIGNOR-154810
mTORC1EIF4EBP1–phosphorylation
down-regulates activity
20670887SIGNOR-235745
MAPK1EIF4EBP1Ser83 PTIPGVTsPSSDEPPphosphorylation
down-regulates activity
11691836SIGNOR-249391
CDK1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
11553333SIGNOR-110416
mTORC1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
10942774SIGNOR-236702
MTOREIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
12747827SIGNOR-101123
mTORC1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
23486913SIGNOR-217141
mTORC1EIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
9465032SIGNOR-217090
MTOREIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
23486913SIGNOR-219257
RPS6KA5EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
12213813SIGNOR-262994
PRKCDEIF4EBP1–phosphorylation
down-regulates activity
10698949SIGNOR-279100
RPS6KA5EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
12213813SIGNOR-262991
mTORC1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
12747827SIGNOR-235964
MTOREIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
23486913SIGNOR-219273
RPS6KA5EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
12213813SIGNOR-262992
PIM2EIF4EBP1–phosphorylation
up-regulates activity
19290049SIGNOR-279091
GSK3BEIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
18701453SIGNOR-236660
CyclinK/CDK13EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
up-regulates activity
36882522SIGNOR-273114
MTOREIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
17510057SIGNOR-154814
mTORC1EIF4EBP1–phosphorylation
down-regulates activity
17510057SIGNOR-235748
MAPK14EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
11777913SIGNOR-250098
MTOREIF4EBP1Thr36LPPGDYStTPGGTLFphosphorylation
down-regulates activity
20670887SIGNOR-167180
MTOREIF4EBP1Ser83 PTIPGVTsPSSDEPPphosphorylation
down-regulates activity
9204908SIGNOR-250292
MTOREIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
10942774SIGNOR-226714
mTORC1EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
23486913SIGNOR-217110
CSNK2A2EIF4EBP1Ser112 KRAGGEEsQFEMDIphosphorylation
down-regulates activity
9806882SIGNOR-249334
mTORC1EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
23486913SIGNOR-217137
MAPK1EIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates
11777913SIGNOR-113563
MTOREIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
12747827SIGNOR-101127
CDK13EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
up-regulates activity
36882522SIGNOR-273113
mTORC1EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
12747827SIGNOR-236698
MAPK1EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
11691836SIGNOR-249393
mTORC1EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
12747827SIGNOR-236690
MTOREIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
10942774SIGNOR-226710
MTOREIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
12747827SIGNOR-101119
MAPK1EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
11691836SIGNOR-249392
MAPK1EIF4EBP1Thr70 RNSPVTKtPPRDLPTphosphorylation
down-regulates activity
11691836SIGNOR-249394
CSNK1EEIF4EBP1Thr41 YSTTPGGtLFSTTPGphosphorylation
down-regulates
24247720SIGNOR-203240
MTOREIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
23486913SIGNOR-219266
CSNK1EEIF4EBP1Thr50FSTTPGGtRIIYDRKphosphorylation
down-regulates
24247720SIGNOR-203276
mTORC1EIF4EBP1Thr46 GGTLFSTtPGGTRIIphosphorylation
down-regulates activity
23486913SIGNOR-217114
mTORC1EIF4EBP1Thr37 PPGDYSTtPGGTLFSphosphorylation
down-regulates activity
12747827SIGNOR-236694
RPS6KA5EIF4EBP1Ser65 FLMECRNsPVTKTPPphosphorylation
down-regulates activity
12213813SIGNOR-262993
mTORC1EIF4EBP1–phosphorylation
down-regulates activity
12747827SIGNOR-236678
MTOREIF4EBP1Thr45 PGGTLFStTPGGTRIphosphorylation
down-regulates activity
20670887SIGNOR-167184
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr36
phosphorylation
down-regulates
⊣
EIF4EBP19465032SIGNOR-55697
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr36
phosphorylation
down-regulates
⊣
EIF4EBP19465032SIGNOR-217086
MAPK14phosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP111777913SIGNOR-250099
RPS6KA5phosphorylation
up-regulates
→
EIF4EBP1
PThr45
phosphorylation
down-regulates
⊣
EIF4EBP111777913SIGNOR-249131
CSNK2A1phosphorylation
up-regulates
→
EIF4EBP1
PSer112
phosphorylation
down-regulates
⊣
EIF4EBP112588975SIGNOR-98280
GSK3Bphosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP123584478SIGNOR-201699
MTORphosphorylation
up-regulates
→
EIF4EBP1
PSer65
phosphorylation
down-regulates
⊣
EIF4EBP112747827SIGNOR-101115
MAPK1phosphorylation
up-regulates
→
EIF4EBP1
PSer65
phosphorylation
down-regulates
⊣
EIF4EBP111691836SIGNOR-249390
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP110942774SIGNOR-80797
MAPK14phosphorylation
up-regulates
→
EIF4EBP1
PSer65
phosphorylation
down-regulates
⊣
EIF4EBP111777913SIGNOR-250097
GSK3Bphosphorylation
up-regulates
→
EIF4EBP1
PThr37
phosphorylation
down-regulates
⊣
EIF4EBP118701453SIGNOR-236026
ATMphosphorylation
up-regulates
→
EIF4EBP1
PSer112
phosphorylation
down-regulates
⊣
EIF4EBP111146653SIGNOR-85619
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr37
phosphorylation
down-regulates
⊣
EIF4EBP123486913SIGNOR-219262
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr45
phosphorylation
down-regulates
⊣
EIF4EBP19465032SIGNOR-55701
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr36
phosphorylation
down-regulates
⊣
EIF4EBP117510057SIGNOR-154810
MAPK1phosphorylation
up-regulates
→
EIF4EBP1
PSer83
phosphorylation
down-regulates
⊣
EIF4EBP111691836SIGNOR-249391
CDK1phosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP111553333SIGNOR-110416
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP110942774SIGNOR-236702
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP112747827SIGNOR-101123
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP123486913SIGNOR-217141
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr45
phosphorylation
down-regulates
⊣
EIF4EBP19465032SIGNOR-217090
MTORphosphorylation
up-regulates
→
EIF4EBP1
PSer65
phosphorylation
down-regulates
⊣
EIF4EBP123486913SIGNOR-219257
RPS6KA5phosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP112213813SIGNOR-262994
RPS6KA5phosphorylation
up-regulates
→
EIF4EBP1
PThr37
phosphorylation
down-regulates
⊣
EIF4EBP112213813SIGNOR-262991
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP112747827SIGNOR-235964
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP123486913SIGNOR-219273
RPS6KA5phosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP112213813SIGNOR-262992
GSK3Bphosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP118701453SIGNOR-236660
CyclinK/CDK13phosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
up-regulates
→
EIF4EBP136882522SIGNOR-273114
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr45
phosphorylation
down-regulates
⊣
EIF4EBP117510057SIGNOR-154814
MAPK14phosphorylation
up-regulates
→
EIF4EBP1
PThr37
phosphorylation
down-regulates
⊣
EIF4EBP111777913SIGNOR-250098
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr36
phosphorylation
down-regulates
⊣
EIF4EBP120670887SIGNOR-167180
MTORphosphorylation
up-regulates
→
EIF4EBP1
PSer83
phosphorylation
down-regulates
⊣
EIF4EBP19204908SIGNOR-250292
MTORphosphorylation
up-regulates
→
EIF4EBP1
PSer65
phosphorylation
down-regulates
⊣
EIF4EBP110942774SIGNOR-226714
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr37
phosphorylation
down-regulates
⊣
EIF4EBP123486913SIGNOR-217110
CSNK2A2phosphorylation
up-regulates
→
EIF4EBP1
PSer112
phosphorylation
down-regulates
⊣
EIF4EBP19806882SIGNOR-249334
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PSer65
phosphorylation
down-regulates
⊣
EIF4EBP123486913SIGNOR-217137
MAPK1phosphorylation
up-regulates
→
EIF4EBP1
PThr45
phosphorylation
down-regulates
⊣
EIF4EBP111777913SIGNOR-113563
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP112747827SIGNOR-101127
CDK13phosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
up-regulates
→
EIF4EBP136882522SIGNOR-273113
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP112747827SIGNOR-236698
MAPK1phosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP111691836SIGNOR-249393
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PSer65
phosphorylation
down-regulates
⊣
EIF4EBP112747827SIGNOR-236690
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP110942774SIGNOR-226710
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr37
phosphorylation
down-regulates
⊣
EIF4EBP112747827SIGNOR-101119
MAPK1phosphorylation
up-regulates
→
EIF4EBP1
PThr37
phosphorylation
down-regulates
⊣
EIF4EBP111691836SIGNOR-249392
MAPK1phosphorylation
up-regulates
→
EIF4EBP1
PThr70
phosphorylation
down-regulates
⊣
EIF4EBP111691836SIGNOR-249394
CSNK1Ephosphorylation
up-regulates
→
EIF4EBP1
PThr41
phosphorylation
down-regulates
⊣
EIF4EBP124247720SIGNOR-203240
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP123486913SIGNOR-219266
CSNK1Ephosphorylation
up-regulates
→
EIF4EBP1
PThr50
phosphorylation
down-regulates
⊣
EIF4EBP124247720SIGNOR-203276
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr46
phosphorylation
down-regulates
⊣
EIF4EBP123486913SIGNOR-217114
mTORC1phosphorylation
up-regulates
→
EIF4EBP1
PThr37
phosphorylation
down-regulates
⊣
EIF4EBP112747827SIGNOR-236694
RPS6KA5phosphorylation
up-regulates
→
EIF4EBP1
PSer65
phosphorylation
down-regulates
⊣
EIF4EBP112213813SIGNOR-262993
MTORphosphorylation
up-regulates
→
EIF4EBP1
PThr45
phosphorylation
down-regulates
⊣
EIF4EBP120670887SIGNOR-167184
Regulator Mechanism/Effect Target SIGNOR-ID
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-55697
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-217086
MAPK14phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-250099
RPS6KA5phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-249131
CSNK2A1phosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-98280
GSK3Bphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-201699
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-101115
MAPK1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-249390
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-80797
MAPK14phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-250097
GSK3Bphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-236026
ATMphosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-85619
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-219262
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-55701
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-154810
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-235745
MAPK1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-249391
CDK1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-110416
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-236702
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-101123
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-217141
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-217090
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-219257
RPS6KA5phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-262994
PRKCDphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-279100
RPS6KA5phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-262991
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-235964
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-219273
RPS6KA5phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-262992
PIM2phosphorylation
→
up-regulates activity
EIF4EBP1SIGNOR-279091
GSK3Bphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-236660
CyclinK/CDK13phosphorylation
→
up-regulates activity
EIF4EBP1SIGNOR-273114
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-154814
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-235748
MAPK14phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-250098
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-167180
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-250292
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-226714
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-217110
CSNK2A2phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-249334
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-217137
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-113563
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-101127
CDK13phosphorylation
→
up-regulates activity
EIF4EBP1SIGNOR-273113
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-236698
MAPK1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-249393
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-236690
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-226710
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-101119
MAPK1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-249392
MAPK1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-249394
CSNK1Ephosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-203240
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-219266
CSNK1Ephosphorylation
img/direct_inhibition.png
down-regulates
EIF4EBP1SIGNOR-203276
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-217114
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-236694
RPS6KA5phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-262993
mTORC1phosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-236678
MTORphosphorylation
→
down-regulates activity
EIF4EBP1SIGNOR-167184