| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | EIF4EBP1 | Ser83 | PTIPGVTsPSSDEPP | phosphorylation down-regulates activity | 9204908 | SIGNOR-250292 |
| MAPK1 | EIF4EBP1 | Ser83 | PTIPGVTsPSSDEPP | phosphorylation down-regulates activity | 11691836 | SIGNOR-249391 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PSer83 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 9204908 | SIGNOR-250292 |
| MAPK1 | phosphorylation up-regulates → | EIF4EBP1 PSer83 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 11691836 | SIGNOR-249391 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-250292 |
| MAPK1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-249391 |