| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC1 | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 12747827 | SIGNOR-236690 |
| MTOR | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 23486913 | SIGNOR-219257 |
| mTORC1 | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 23486913 | SIGNOR-217137 |
| MTOR | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 10942774 | SIGNOR-226714 |
| MTOR | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 12747827 | SIGNOR-101115 |
| MAPK1 | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 11691836 | SIGNOR-249390 |
| MAPK14 | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 11777913 | SIGNOR-250097 |
| RPS6KA5 | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 12213813 | SIGNOR-262993 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-236690 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-219257 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-217137 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 10942774 | SIGNOR-226714 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-101115 |
| MAPK1 | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 11691836 | SIGNOR-249390 |
| MAPK14 | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 11777913 | SIGNOR-250097 |
| RPS6KA5 | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12213813 | SIGNOR-262993 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236690 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-219257 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217137 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-226714 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-101115 |
| MAPK1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-249390 |
| MAPK14 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-250097 |
| RPS6KA5 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-262993 |
