Entity Details

Name	RPS6KA5_Thr45
ID	Q13541
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
mTORC1	EIF4EBP1	Thr45	PGGTLFStTPGGTRI	phosphorylation down-regulates activity	9465032	SIGNOR-217090
MAPK1	EIF4EBP1	Thr45	PGGTLFStTPGGTRI	phosphorylation down-regulates	11777913	SIGNOR-113563
MTOR	EIF4EBP1	Thr45	PGGTLFStTPGGTRI	phosphorylation down-regulates activity	9465032	SIGNOR-55701
RPS6KA5	EIF4EBP1	Thr45	PGGTLFStTPGGTRI	phosphorylation down-regulates activity	11777913	SIGNOR-249131
MTOR	EIF4EBP1	Thr45	PGGTLFStTPGGTRI	phosphorylation down-regulates activity	17510057	SIGNOR-154814
MTOR	EIF4EBP1	Thr45	PGGTLFStTPGGTRI	phosphorylation down-regulates activity	20670887	SIGNOR-167184

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
mTORC1	phosphorylation up-regulates →	EIF4EBP1 PThr45	phosphorylation down-regulates ⊣	EIF4EBP1	9465032	SIGNOR-217090
MAPK1	phosphorylation up-regulates →	EIF4EBP1 PThr45	phosphorylation down-regulates ⊣	EIF4EBP1	11777913	SIGNOR-113563
MTOR	phosphorylation up-regulates →	EIF4EBP1 PThr45	phosphorylation down-regulates ⊣	EIF4EBP1	9465032	SIGNOR-55701
RPS6KA5	phosphorylation up-regulates →	EIF4EBP1 PThr45	phosphorylation down-regulates ⊣	EIF4EBP1	11777913	SIGNOR-249131
MTOR	phosphorylation up-regulates →	EIF4EBP1 PThr45	phosphorylation down-regulates ⊣	EIF4EBP1	17510057	SIGNOR-154814
MTOR	phosphorylation up-regulates →	EIF4EBP1 PThr45	phosphorylation down-regulates ⊣	EIF4EBP1	20670887	SIGNOR-167184

Regulator	Mechanism/Effect	Target	SIGNOR-ID
mTORC1	phosphorylation → down-regulates activity	EIF4EBP1	SIGNOR-217090
MAPK1	phosphorylation down-regulates	EIF4EBP1	SIGNOR-113563
MTOR	phosphorylation → down-regulates activity	EIF4EBP1	SIGNOR-55701
RPS6KA5	phosphorylation → down-regulates activity	EIF4EBP1	SIGNOR-249131
MTOR	phosphorylation → down-regulates activity	EIF4EBP1	SIGNOR-154814
MTOR	phosphorylation → down-regulates activity	EIF4EBP1	SIGNOR-167184