| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA5 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 12213813 | SIGNOR-262992 |
| CyclinK/CDK13 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation up-regulates activity | 36882522 | SIGNOR-273114 |
| MTOR | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 12747827 | SIGNOR-101123 |
| MAPK14 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 11777913 | SIGNOR-250099 |
| GSK3B | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 23584478 | SIGNOR-201699 |
| mTORC1 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 23486913 | SIGNOR-217114 |
| GSK3B | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 18701453 | SIGNOR-236660 |
| MTOR | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 23486913 | SIGNOR-219266 |
| CDK13 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation up-regulates activity | 36882522 | SIGNOR-273113 |
| mTORC1 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 12747827 | SIGNOR-236698 |
| MAPK1 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 11691836 | SIGNOR-249393 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA5 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12213813 | SIGNOR-262992 |
| CyclinK/CDK13 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation up-regulates → | EIF4EBP1 | 36882522 | SIGNOR-273114 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-101123 |
| MAPK14 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 11777913 | SIGNOR-250099 |
| GSK3B | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23584478 | SIGNOR-201699 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-217114 |
| GSK3B | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 18701453 | SIGNOR-236660 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-219266 |
| CDK13 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation up-regulates → | EIF4EBP1 | 36882522 | SIGNOR-273113 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-236698 |
| MAPK1 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 11691836 | SIGNOR-249393 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA5 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-262992 |
| CyclinK/CDK13 | phosphorylation → up-regulates activity | EIF4EBP1 | SIGNOR-273114 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-101123 |
| MAPK14 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-250099 |
| GSK3B | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-201699 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217114 |
| GSK3B | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236660 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-219266 |
| CDK13 | phosphorylation → up-regulates activity | EIF4EBP1 | SIGNOR-273113 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236698 |
| MAPK1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-249393 |
