| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 11691836 | SIGNOR-249394 |
| MTOR | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 10942774 | SIGNOR-80797 |
| CDK1 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 11553333 | SIGNOR-110416 |
| mTORC1 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 10942774 | SIGNOR-236702 |
| mTORC1 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 23486913 | SIGNOR-217141 |
| RPS6KA5 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 12213813 | SIGNOR-262994 |
| mTORC1 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 12747827 | SIGNOR-235964 |
| MTOR | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 23486913 | SIGNOR-219273 |
| MTOR | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 12747827 | SIGNOR-101127 |
| MTOR | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 10942774 | SIGNOR-226710 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 11691836 | SIGNOR-249394 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 10942774 | SIGNOR-80797 |
| CDK1 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 11553333 | SIGNOR-110416 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 10942774 | SIGNOR-236702 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-217141 |
| RPS6KA5 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12213813 | SIGNOR-262994 |
| mTORC1 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-235964 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 23486913 | SIGNOR-219273 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12747827 | SIGNOR-101127 |
| MTOR | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 10942774 | SIGNOR-226710 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-249394 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-80797 |
| CDK1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-110416 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-236702 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-217141 |
| RPS6KA5 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-262994 |
| mTORC1 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-235964 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-219273 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-101127 |
| MTOR | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-226710 |
