| Name | RIPK1 |
| ID | Q13546 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 17-289 PROSITE-ProRule
Death 583-669 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK1 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 34654937 | SIGNOR-280104 |
| RIPK1 | MAP3K1 | – | phosphorylation up-regulates | 11369754 | SIGNOR-108260 | |
| RIPK1 | MAP3K1 | Ser970 | HSQCLNSsPLSHHSQ | phosphorylation up-regulates activity | 11369754 | SIGNOR-108257 |
| RIPK1 | RIPK1 | Ser14 | LNVIKMKsSDFLESA | phosphorylation up-regulates activity | 18408713 | SIGNOR-276161 |
| RIPK1 | RIPK1 | Ser15 | NVIKMKSsDFLESAE | phosphorylation up-regulates activity | 18408713 | SIGNOR-276162 |
| RIPK1 | RIPK1 | Ser161 | IADLGLAsFKMWSKL | phosphorylation up-regulates activity | 18408713 | SIGNOR-276158 |
| RIPK1 | RIPK1 | Ser166 | LASFKMWsKLNNEEH | phosphorylation up-regulates activity | 18408713 | SIGNOR-276159 |
| RIPK1 | RIPK1 | Ser20 | KSSDFLEsAELDSGG | phosphorylation up-regulates activity | 18408713 | SIGNOR-276160 |
| RIPK1 | DAB2IP | Ser728 | PSPARSSsYSEANEP | phosphorylation up-regulates activity | 17389591 | SIGNOR-259976 |
| RIPK1 | DAB2IP | Ser728 | PSPARSSsYSEANEP | phosphorylation up-regulates activity | 27858941 | SIGNOR-254763 |
| RIPK1 | MPRIP | – | phosphorylation up-regulates activity | 24653026 | SIGNOR-279755 | |
| RIPK1 | TBK1 | – | phosphorylation up-regulates activity | 36198273 | SIGNOR-279278 | |
| RIPK1 | RIPK3 | – | phosphorylation up-regulates activity | 26694384 | SIGNOR-278429 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK1 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 34654937 | SIGNOR-280104 |
| RIPK1 | phosphorylation up-regulates → | MAP3K1 PSer970 | phosphorylation up-regulates → | MAP3K1 | 11369754 | SIGNOR-108257 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer14 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276161 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer15 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276162 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer161 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276158 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer166 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276159 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer20 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276160 |
| RIPK1 | phosphorylation up-regulates → | DAB2IP PSer728 | phosphorylation up-regulates → | DAB2IP | 17389591 | SIGNOR-259976 |
| RIPK1 | phosphorylation up-regulates → | DAB2IP PSer728 | phosphorylation up-regulates → | DAB2IP | 27858941 | SIGNOR-254763 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RIPK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-280104 |
| RIPK1 | phosphorylation → up-regulates | MAP3K1 | SIGNOR-108260 |
| RIPK1 | phosphorylation → up-regulates activity | MAP3K1 | SIGNOR-108257 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276161 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276162 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276158 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276159 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276160 |
| RIPK1 | phosphorylation → up-regulates activity | DAB2IP | SIGNOR-259976 |
| RIPK1 | phosphorylation → up-regulates activity | DAB2IP | SIGNOR-254763 |
| RIPK1 | phosphorylation → up-regulates activity | MPRIP | SIGNOR-279755 |
| RIPK1 | phosphorylation → up-regulates activity | TBK1 | SIGNOR-279278 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK3 | SIGNOR-278429 |