| Name | RIPK1 |
| ID | Q13546 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 17-289 PROSITE-ProRule
Death 583-669 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | RIPK1 | Thr189 | TAKKNGGtLYYMAPE | phosphorylation down-regulates activity | 30146158 | SIGNOR-279388 |
| RIPK1 | RIPK1 | Ser166 | LASFKMWsKLNNEEH | phosphorylation up-regulates activity | 18408713 | SIGNOR-276159 |
| JAK1 | RIPK1 | Tyr384 | KLQDEANyHLYGSRM | phosphorylation up-regulates activity | 36329033 | SIGNOR-278948 |
| RIPK1 | RIPK1 | Ser161 | IADLGLAsFKMWSKL | phosphorylation up-regulates activity | 18408713 | SIGNOR-276158 |
| RIPK1 | RIPK1 | Ser15 | NVIKMKSsDFLESAE | phosphorylation up-regulates activity | 18408713 | SIGNOR-276162 |
| RIPK1 | RIPK1 | Ser14 | LNVIKMKsSDFLESA | phosphorylation up-regulates activity | 18408713 | SIGNOR-276161 |
| RIPK1 | RIPK1 | Ser20 | KSSDFLEsAELDSGG | phosphorylation up-regulates activity | 18408713 | SIGNOR-276160 |
| CHUK | RIPK1 | – | phosphorylation down-regulates activity | 26516792 | SIGNOR-278927 | |
| RIPK3 | RIPK1 | – | phosphorylation up-regulates activity | 24535827 | SIGNOR-280106 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | phosphorylation up-regulates → | RIPK1 PThr189 | phosphorylation down-regulates ⊣ | RIPK1 | 30146158 | SIGNOR-279388 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer166 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276159 |
| JAK1 | phosphorylation up-regulates → | RIPK1 PTyr384 | phosphorylation up-regulates → | RIPK1 | 36329033 | SIGNOR-278948 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer161 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276158 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer15 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276162 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer14 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276161 |
| RIPK1 | phosphorylation up-regulates → | RIPK1 PSer20 | phosphorylation up-regulates → | RIPK1 | 18408713 | SIGNOR-276160 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TBK1 | phosphorylation → down-regulates activity | RIPK1 | SIGNOR-279388 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276159 |
| JAK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-278948 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276158 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276162 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276161 |
| RIPK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-276160 |
| CHUK | phosphorylation → down-regulates activity | RIPK1 | SIGNOR-278927 |
| RIPK3 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-280106 |