| Name | ACVR2B |
| ID | Q13705 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 190-480 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ACVR2B | ACVR1B | Thr206 | VQRTVARtIVLQEII | phosphorylation up-regulates activity | 8622651 | SIGNOR-235146 |
| ACVR2B | SMAD3 | – | phosphorylation up-regulates activity | 21966641 | SIGNOR-254985 | |
| ACVR2B | SMAD2 | – | phosphorylation up-regulates activity | 21966641 | SIGNOR-254984 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ACVR2B | phosphorylation up-regulates → | ACVR1B PThr206 | phosphorylation up-regulates → | ACVR1B | 8622651 | SIGNOR-235146 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ACVR2B | phosphorylation → up-regulates activity | ACVR1B | SIGNOR-235146 |
| ACVR2B | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-254985 |
| ACVR2B | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-254984 |