Entity Details

Name RUNX3
ID Q13761
Role substrate
Enzymatic Domains
Runt 54-182
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinD/CDK4RUNX3Ser356SSSGGDRsPTRMLASphosphorylation
down-regulates		19351720SIGNOR-216980
PIM1RUNX3–phosphorylation
up-regulates quantity		24266874SIGNOR-279547
CDK4RUNX3Ser356SSSGGDRsPTRMLASphosphorylation
down-regulates		19351720SIGNOR-185120
SRCRUNX3–phosphorylation
down-regulates activity		20100835SIGNOR-278199
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinD/CDK4phosphorylation
up-regulates
→
RUNX3
PSer356		phosphorylation
down-regulates
⊣		RUNX319351720SIGNOR-216980
CDK4phosphorylation
up-regulates
→
RUNX3
PSer356		phosphorylation
down-regulates
⊣		RUNX319351720SIGNOR-185120
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinD/CDK4phosphorylation
img/direct_inhibition.png
down-regulates 		RUNX3SIGNOR-216980
PIM1phosphorylation
→
up-regulates quantity 		RUNX3SIGNOR-279547
CDK4phosphorylation
img/direct_inhibition.png
down-regulates 		RUNX3SIGNOR-185120
SRCphosphorylation
→
down-regulates activity 		RUNX3SIGNOR-278199