| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD/CDK4 | RUNX3 | Ser356 | SSSGGDRsPTRMLAS | phosphorylation down-regulates | 19351720 | SIGNOR-216980 |
| CDK4 | RUNX3 | Ser356 | SSSGGDRsPTRMLAS | phosphorylation down-regulates | 19351720 | SIGNOR-185120 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD/CDK4 | phosphorylation up-regulates → | RUNX3 PSer356 | phosphorylation down-regulates ⊣ | RUNX3 | 19351720 | SIGNOR-216980 |
| CDK4 | phosphorylation up-regulates → | RUNX3 PSer356 | phosphorylation down-regulates ⊣ | RUNX3 | 19351720 | SIGNOR-185120 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinD/CDK4 | phosphorylation![]() down-regulates | RUNX3 | SIGNOR-216980 |
| CDK4 | phosphorylation![]() down-regulates | RUNX3 | SIGNOR-185120 |