| Name | PTK6 |
| ID | Q13882 |
| Role | kinase |
| Enzymatic Domains |
SH3 8-72 PROSITE-ProRule
SH2 78-170 PROSITE-ProRule
Protein kinase 191-445 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK6 | CBL | – | phosphorylation down-regulates activity | 23352614 | SIGNOR-279348 | |
| PTK6 | SFPQ | – | phosphorylation down-regulates activity | 19439179 | SIGNOR-279754 | |
| PTK6 | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-252617 |
| PTK6 | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 20606012 | SIGNOR-252618 |
| PTK6 | AKT1 | Tyr326 | EVLEDNDyGRAVDWW | phosphorylation up-regulates | 20606012 | SIGNOR-252622 |
| PTK6 | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation down-regulates quantity | 20026641 | SIGNOR-278286 |
| PTK6 | CTNNB1 | Tyr331 | LVNIMRTyTYEKLLW | phosphorylation down-regulates quantity | 20026641 | SIGNOR-278287 |
| PTK6 | CTNNB1 | Tyr333 | NIMRTYTyEKLLWTT | phosphorylation down-regulates quantity | 20026641 | SIGNOR-278289 |
| PTK6 | CTNNB1 | Tyr64 | VDTSQVLyEWEQGFS | phosphorylation down-regulates quantity | 20026641 | SIGNOR-278288 |
| PTK6 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 26247733 | SIGNOR-278346 |
| PTK6 | PXN | – | phosphorylation up-regulates activity | 33391524 | SIGNOR-280102 | |
| PTK6 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | phosphorylation up-regulates | 17997837 | SIGNOR-159066 |
| PTK6 | BCAR1 | Tyr664 | EGGWMEDyDYVHLQG | phosphorylation up-regulates | 22084245 | SIGNOR-177242 |
| PTK6 | BCAR1 | Tyr165 | PSPATDLyQVPPGPG | phosphorylation up-regulates activity | 22084245 | SIGNOR-177238 |
| PTK6 | CNTNAP1 | – | phosphorylation up-regulates activity | 18829532 | SIGNOR-279274 | |
| PTK6 | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates activity | 23027128 | SIGNOR-278428 |
| PTK6 | KHDRBS1 | Tyr435 | ARPVKGAyREHPYGR | phosphorylation unknown | 16179349 | SIGNOR-249293 |
| PTK6 | KHDRBS1 | Tyr440 | GAYREHPyGRY | phosphorylation unknown | 16179349 | SIGNOR-249294 |
| PTK6 | KHDRBS1 | Tyr443 | REHPYGRy | phosphorylation unknown | 16179349 | SIGNOR-249292 |
| PTK6 | KHDRBS1 | – | phosphorylation up-regulates | 10913193 | SIGNOR-80020 | |
| PTK6 | EPS8 | Tyr498 | YAFSSNIyTRGSHLD | phosphorylation up-regulates activity | 27738316 | SIGNOR-263189 |
| PTK6 | EPS8 | Tyr525 | NRHIDRNyEPLKTQP | phosphorylation up-regulates activity | 28214294 | SIGNOR-263190 |
| PTK6 | EPS8 | Tyr535 | LKTQPKKyAKSKYDF | phosphorylation up-regulates activity | 28214294 | SIGNOR-263191 |
| PTK6 | ARHGAP5 | Tyr1109 | KGYSDEIyVVPDDSQ | phosphorylation up-regulates | 18829532 | SIGNOR-181452 |
| PTK6 | PTK6 | Tyr342 | RLIKEDVyLSHDHNI | phosphorylation up-regulates | 12121988 | SIGNOR-90604 |
| PTK6 | PTK6 | Tyr447 | RLSSFTSyENPT | phosphorylation up-regulates activity | 12121988 | SIGNOR-249152 |
| PTK6 | CDC73 | – | phosphorylation down-regulates activity | 27650679 | SIGNOR-279273 | |
| PTK6 | ARAP1 | Tyr231 | PEFDDSDyDEVPEEG | phosphorylation up-regulates activity | 20554524 | SIGNOR-263188 |
| PTK6 | DOK1 | Tyr362 | DPKEDPIyDEPEGLA | phosphorylation down-regulates activity | 24523872 | SIGNOR-278301 |
| PTK6 | STAP2 | – | phosphorylation up-regulates | 10980601 | SIGNOR-81489 | |
| PTK6 | STAP2 | Tyr250 | PFLLDEDyEKVLGYV | phosphorylation up-regulates activity | 19393627 | SIGNOR-247067 |
| PTK6 | AKT | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-138437 |
| PTK6 | AKT | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 20606012 | SIGNOR-166506 |
| PTK6 | AKT | Tyr326 | EVLEDNDyGRAVDWW | phosphorylation up-regulates | 20606012 | SIGNOR-166510 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK6 | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 15994200 | SIGNOR-252617 |
| PTK6 | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 20606012 | SIGNOR-252618 |
| PTK6 | phosphorylation up-regulates → | AKT1 PTyr326 | phosphorylation up-regulates → | AKT1 | 20606012 | SIGNOR-252622 |
| PTK6 | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation down-regulates ⊣ | CTNNB1 | 20026641 | SIGNOR-278286 |
| PTK6 | phosphorylation up-regulates → | CTNNB1 PTyr331 | phosphorylation down-regulates ⊣ | CTNNB1 | 20026641 | SIGNOR-278287 |
| PTK6 | phosphorylation up-regulates → | CTNNB1 PTyr333 | phosphorylation down-regulates ⊣ | CTNNB1 | 20026641 | SIGNOR-278289 |
| PTK6 | phosphorylation up-regulates → | CTNNB1 PTyr64 | phosphorylation down-regulates ⊣ | CTNNB1 | 20026641 | SIGNOR-278288 |
| PTK6 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 26247733 | SIGNOR-278346 |
| PTK6 | phosphorylation up-regulates → | STAT5B PTyr699 | phosphorylation up-regulates → | STAT5B | 17997837 | SIGNOR-159066 |
| PTK6 | phosphorylation up-regulates → | BCAR1 PTyr664 | phosphorylation up-regulates → | BCAR1 | 22084245 | SIGNOR-177242 |
| PTK6 | phosphorylation up-regulates → | BCAR1 PTyr165 | phosphorylation up-regulates → | BCAR1 | 22084245 | SIGNOR-177238 |
| PTK6 | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 23027128 | SIGNOR-278428 |
| PTK6 | phosphorylation up-regulates → | KHDRBS1 PTyr435 | phosphorylation down-regulates ⊣ | KHDRBS1 | 16179349 | SIGNOR-249293 |
| PTK6 | phosphorylation up-regulates → | KHDRBS1 PTyr440 | phosphorylation down-regulates ⊣ | KHDRBS1 | 16179349 | SIGNOR-249294 |
| PTK6 | phosphorylation up-regulates → | KHDRBS1 PTyr443 | phosphorylation down-regulates ⊣ | KHDRBS1 | 16179349 | SIGNOR-249292 |
| PTK6 | phosphorylation up-regulates → | EPS8 PTyr498 | phosphorylation up-regulates → | EPS8 | 27738316 | SIGNOR-263189 |
| PTK6 | phosphorylation up-regulates → | EPS8 PTyr525 | phosphorylation up-regulates → | EPS8 | 28214294 | SIGNOR-263190 |
| PTK6 | phosphorylation up-regulates → | EPS8 PTyr535 | phosphorylation up-regulates → | EPS8 | 28214294 | SIGNOR-263191 |
| PTK6 | phosphorylation up-regulates → | ARHGAP5 PTyr1109 | phosphorylation up-regulates → | ARHGAP5 | 18829532 | SIGNOR-181452 |
| PTK6 | phosphorylation up-regulates → | PTK6 PTyr342 | phosphorylation up-regulates → | PTK6 | 12121988 | SIGNOR-90604 |
| PTK6 | phosphorylation up-regulates → | PTK6 PTyr447 | phosphorylation up-regulates → | PTK6 | 12121988 | SIGNOR-249152 |
| PTK6 | phosphorylation up-regulates → | ARAP1 PTyr231 | phosphorylation up-regulates → | ARAP1 | 20554524 | SIGNOR-263188 |
| PTK6 | phosphorylation up-regulates → | DOK1 PTyr362 | phosphorylation down-regulates ⊣ | DOK1 | 24523872 | SIGNOR-278301 |
| PTK6 | phosphorylation up-regulates → | STAP2 PTyr250 | phosphorylation up-regulates → | STAP2 | 19393627 | SIGNOR-247067 |
| PTK6 | phosphorylation up-regulates → | AKT PTyr315 | phosphorylation up-regulates → | AKT | 15994200 | SIGNOR-138437 |
| PTK6 | phosphorylation up-regulates → | AKT PTyr315 | phosphorylation up-regulates → | AKT | 20606012 | SIGNOR-166506 |
| PTK6 | phosphorylation up-regulates → | AKT PTyr326 | phosphorylation up-regulates → | AKT | 20606012 | SIGNOR-166510 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK6 | phosphorylation → down-regulates activity | CBL | SIGNOR-279348 |
| PTK6 | phosphorylation → down-regulates activity | SFPQ | SIGNOR-279754 |
| PTK6 | phosphorylation → up-regulates | AKT1 | SIGNOR-252617 |
| PTK6 | phosphorylation → up-regulates | AKT1 | SIGNOR-252618 |
| PTK6 | phosphorylation → up-regulates | AKT1 | SIGNOR-252622 |
| PTK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278286 |
| PTK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278287 |
| PTK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278289 |
| PTK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278288 |
| PTK6 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-278346 |
| PTK6 | phosphorylation → up-regulates activity | PXN | SIGNOR-280102 |
| PTK6 | phosphorylation → up-regulates | STAT5B | SIGNOR-159066 |
| PTK6 | phosphorylation → up-regulates | BCAR1 | SIGNOR-177242 |
| PTK6 | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-177238 |
| PTK6 | phosphorylation → up-regulates activity | CNTNAP1 | SIGNOR-279274 |
| PTK6 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-278428 |
| PTK6 | phosphorylation → unknown | KHDRBS1 | SIGNOR-249293 |
| PTK6 | phosphorylation → unknown | KHDRBS1 | SIGNOR-249294 |
| PTK6 | phosphorylation → unknown | KHDRBS1 | SIGNOR-249292 |
| PTK6 | phosphorylation → up-regulates | KHDRBS1 | SIGNOR-80020 |
| PTK6 | phosphorylation → up-regulates activity | EPS8 | SIGNOR-263189 |
| PTK6 | phosphorylation → up-regulates activity | EPS8 | SIGNOR-263190 |
| PTK6 | phosphorylation → up-regulates activity | EPS8 | SIGNOR-263191 |
| PTK6 | phosphorylation → up-regulates | ARHGAP5 | SIGNOR-181452 |
| PTK6 | phosphorylation → up-regulates | PTK6 | SIGNOR-90604 |
| PTK6 | phosphorylation → up-regulates activity | PTK6 | SIGNOR-249152 |
| PTK6 | phosphorylation → down-regulates activity | CDC73 | SIGNOR-279273 |
| PTK6 | phosphorylation → up-regulates activity | ARAP1 | SIGNOR-263188 |
| PTK6 | phosphorylation → down-regulates activity | DOK1 | SIGNOR-278301 |
| PTK6 | phosphorylation → up-regulates | STAP2 | SIGNOR-81489 |
| PTK6 | phosphorylation → up-regulates activity | STAP2 | SIGNOR-247067 |
| PTK6 | phosphorylation → up-regulates | AKT | SIGNOR-138437 |
| PTK6 | phosphorylation → up-regulates | AKT | SIGNOR-166506 |
| PTK6 | phosphorylation → up-regulates | AKT | SIGNOR-166510 |