| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | PTK6 | Tyr342 | RLIKEDVyLSHDHNI | dephosphorylation down-regulates activity | 29142193 | SIGNOR-276975 |
| PTPN1 | PTK6 | Tyr342 | RLIKEDVyLSHDHNI | dephosphorylation down-regulates activity | 29142193 | SIGNOR-277082 |
| PTK6 | PTK6 | Tyr342 | RLIKEDVyLSHDHNI | phosphorylation up-regulates | 12121988 | SIGNOR-90604 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | dephosphorylation down-regulates ⊣ | PTK6 PTyr342 | dephosphorylation up-regulates → | PTK6 | 29142193 | SIGNOR-276975 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTK6 PTyr342 | dephosphorylation up-regulates → | PTK6 | 29142193 | SIGNOR-277082 |
| PTK6 | phosphorylation up-regulates → | PTK6 PTyr342 | phosphorylation up-regulates → | PTK6 | 12121988 | SIGNOR-90604 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTEN | dephosphorylation → down-regulates activity | PTK6 | SIGNOR-276975 |
| PTPN1 | dephosphorylation → down-regulates activity | PTK6 | SIGNOR-277082 |
| PTK6 | phosphorylation → up-regulates | PTK6 | SIGNOR-90604 |
