Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
GTF2H2	ESR1	Ser118	LHPPPQLsPFLQPHG	phosphorylation up-regulates activity	10949034	SIGNOR-260817

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
GTF2H2	phosphorylation up-regulates →	ESR1 PSer118	phosphorylation up-regulates →	ESR1	10949034	SIGNOR-260817

Regulator	Mechanism/Effect	Target	SIGNOR-ID
GTF2H2	phosphorylation → up-regulates activity	ESR1	SIGNOR-260817