| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HCK | RAPGEF1 | Tyr504 | APIPSVPyAPFAAIL | phosphorylation up-regulates | 24396067 | SIGNOR-203613 |
| ABL1 | RAPGEF1 | Tyr504 | APIPSVPyAPFAAIL | phosphorylation unknown | 20581864 | SIGNOR-166422 |
| SRC | RAPGEF1 | Tyr504 | APIPSVPyAPFAAIL | phosphorylation up-regulates | 15320955 | SIGNOR-128273 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HCK | phosphorylation up-regulates → | RAPGEF1 PTyr504 | phosphorylation up-regulates → | RAPGEF1 | 24396067 | SIGNOR-203613 |
| ABL1 | phosphorylation up-regulates → | RAPGEF1 PTyr504 | phosphorylation down-regulates ⊣ | RAPGEF1 | 20581864 | SIGNOR-166422 |
| SRC | phosphorylation up-regulates → | RAPGEF1 PTyr504 | phosphorylation up-regulates → | RAPGEF1 | 15320955 | SIGNOR-128273 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HCK | phosphorylation → up-regulates | RAPGEF1 | SIGNOR-203613 |
| ABL1 | phosphorylation → unknown | RAPGEF1 | SIGNOR-166422 |
| SRC | phosphorylation → up-regulates | RAPGEF1 | SIGNOR-128273 |
