| Name | CAMK1 |
| ID | Q14012 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 20-276 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK1 | DNM1L | Ser637 | VPVARKLsAREQRDC | phosphorylation up-regulates activity | 31063459 | SIGNOR-262552 |
| CAMK1 | EIF4G3 | Ser1156 | NTFMRGGsSKDLLDN | phosphorylation unknown | 14507913 | SIGNOR-250613 |
| CAMK1 | KRT18 | Ser53 | ISVSRSTsFRGGMGS | phosphorylation unknown | 7523419 | SIGNOR-27398 |
| CAMK1 | SYN1 | Ser9 | NYLRRRLsDSNFMAN | phosphorylation down-regulates activity | 10571231 | SIGNOR-250615 |
| CAMK1 | ATF1 | Ser63 | GILARRPsYRKILKD | phosphorylation up-regulates activity | 8663317 | SIGNOR-250611 |
| CAMK1 | NOS1 | Ser852 | SYKVRFNsVSSYSDS | phosphorylation down-regulates activity | 10400690 | SIGNOR-250614 |
| CAMK1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation up-regulates activity | 23707388 | SIGNOR-261195 |
| CAMK1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation up-regulates activity | 23707388 | SIGNOR-261194 |
| CAMK1 | NUMB | Ser276 | EQLARQGsFRGFPAL | phosphorylation down-regulates | 17022975 | SIGNOR-149993 |
| CAMK1 | CAMK1 | Thr177 | DPGSVLStACGTPGY | phosphorylation up-regulates activity | 8253780 | SIGNOR-250612 |
| CAMK1 | ARHGEF2 | Thr103 | AALLKNNtALQSVSL | phosphorylation up-regulates activity | 28652571 | SIGNOR-279359 |
| CAMK1 | GCM1 | Ser47 | YAKHIYSsEDKNAQR | phosphorylation up-regulates activity | 21791615 | SIGNOR-262680 |
| CAMK1 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates | 11114197 | SIGNOR-85018 |
| CAMK1 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates | 11114197 | SIGNOR-85022 |
| CAMK1 | PPME1 | Ser15 | MHLGRLPsRPPLPGS | phosphorylation down-regulates activity | 24841198 | SIGNOR-265747 |
| CAMK1 | PPME1 | Ser15 | MHLGRLPsRPPLPGS | phosphorylation up-regulates activity | 24841198 | SIGNOR-277827 |
| CAMK1 | PPME1 | Ser15 | MHLGRLPsRPPLPGS | phosphorylation up-regulates activity | 24841198 | SIGNOR-276636 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK1 | phosphorylation up-regulates → | DNM1L PSer637 | phosphorylation up-regulates → | DNM1L | 31063459 | SIGNOR-262552 |
| CAMK1 | phosphorylation up-regulates → | EIF4G3 PSer1156 | phosphorylation down-regulates ⊣ | EIF4G3 | 14507913 | SIGNOR-250613 |
| CAMK1 | phosphorylation up-regulates → | KRT18 PSer53 | phosphorylation down-regulates ⊣ | KRT18 | 7523419 | SIGNOR-27398 |
| CAMK1 | phosphorylation up-regulates → | SYN1 PSer9 | phosphorylation down-regulates ⊣ | SYN1 | 10571231 | SIGNOR-250615 |
| CAMK1 | phosphorylation up-regulates → | ATF1 PSer63 | phosphorylation up-regulates → | ATF1 | 8663317 | SIGNOR-250611 |
| CAMK1 | phosphorylation up-regulates → | NOS1 PSer852 | phosphorylation down-regulates ⊣ | NOS1 | 10400690 | SIGNOR-250614 |
| CAMK1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation up-regulates → | CDKN1B | 23707388 | SIGNOR-261195 |
| CAMK1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation up-regulates → | CDKN1B | 23707388 | SIGNOR-261194 |
| CAMK1 | phosphorylation up-regulates → | NUMB PSer276 | phosphorylation down-regulates ⊣ | NUMB | 17022975 | SIGNOR-149993 |
| CAMK1 | phosphorylation up-regulates → | CAMK1 PThr177 | phosphorylation up-regulates → | CAMK1 | 8253780 | SIGNOR-250612 |
| CAMK1 | phosphorylation up-regulates → | ARHGEF2 PThr103 | phosphorylation up-regulates → | ARHGEF2 | 28652571 | SIGNOR-279359 |
| CAMK1 | phosphorylation up-regulates → | GCM1 PSer47 | phosphorylation up-regulates → | GCM1 | 21791615 | SIGNOR-262680 |
| CAMK1 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 11114197 | SIGNOR-85018 |
| CAMK1 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 11114197 | SIGNOR-85022 |
| CAMK1 | phosphorylation up-regulates → | PPME1 PSer15 | phosphorylation down-regulates ⊣ | PPME1 | 24841198 | SIGNOR-265747 |
| CAMK1 | phosphorylation up-regulates → | PPME1 PSer15 | phosphorylation up-regulates → | PPME1 | 24841198 | SIGNOR-277827 |
| CAMK1 | phosphorylation up-regulates → | PPME1 PSer15 | phosphorylation up-regulates → | PPME1 | 24841198 | SIGNOR-276636 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-262552 |
| CAMK1 | phosphorylation → unknown | EIF4G3 | SIGNOR-250613 |
| CAMK1 | phosphorylation → unknown | KRT18 | SIGNOR-27398 |
| CAMK1 | phosphorylation → down-regulates activity | SYN1 | SIGNOR-250615 |
| CAMK1 | phosphorylation → up-regulates activity | ATF1 | SIGNOR-250611 |
| CAMK1 | phosphorylation → down-regulates activity | NOS1 | SIGNOR-250614 |
| CAMK1 | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-261195 |
| CAMK1 | phosphorylation → up-regulates activity | CDKN1B | SIGNOR-261194 |
| CAMK1 | phosphorylation down-regulates | NUMB | SIGNOR-149993 |
| CAMK1 | phosphorylation → up-regulates activity | CAMK1 | SIGNOR-250612 |
| CAMK1 | phosphorylation → up-regulates activity | ARHGEF2 | SIGNOR-279359 |
| CAMK1 | phosphorylation → up-regulates activity | GCM1 | SIGNOR-262680 |
| CAMK1 | phosphorylation down-regulates | HDAC5 | SIGNOR-85018 |
| CAMK1 | phosphorylation down-regulates | HDAC5 | SIGNOR-85022 |
| CAMK1 | phosphorylation → down-regulates activity | PPME1 | SIGNOR-265747 |
| CAMK1 | phosphorylation → up-regulates activity | PPME1 | SIGNOR-277827 |
| CAMK1 | phosphorylation → up-regulates activity | PPME1 | SIGNOR-276636 |