| Name | ARHGEF7 |
| ID | Q14155 |
| Role | substrate |
| Enzymatic Domains |
Calponin-homology (CH) 1-133 PROSITE-ProRule
SH3 184-243 PROSITE-ProRule
DH 271-451 PROSITE-ProRule
PH 473-578 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCG | ARHGEF7 | Ser518 | LSASPRMsGFIYQGK | phosphorylation up-regulates | 25009260 | SIGNOR-205234 |
| PRKCG | ARHGEF7 | Ser761 | DSLGRRSsLSRLEPS | phosphorylation up-regulates | 25009260 | SIGNOR-205238 |
| LRRK2 | ARHGEF7 | Thr164 | LGSQSLHtRTSKLFQ | phosphorylation up-regulates | 21048939 | SIGNOR-169225 |
| LRRK2 | ARHGEF7 | Thr127 | KVLSSLVtLNKVTAD | phosphorylation up-regulates | 21048939 | SIGNOR-169221 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCG | phosphorylation up-regulates → | ARHGEF7 PSer518 | phosphorylation up-regulates → | ARHGEF7 | 25009260 | SIGNOR-205234 |
| PRKCG | phosphorylation up-regulates → | ARHGEF7 PSer761 | phosphorylation up-regulates → | ARHGEF7 | 25009260 | SIGNOR-205238 |
| LRRK2 | phosphorylation up-regulates → | ARHGEF7 PThr164 | phosphorylation up-regulates → | ARHGEF7 | 21048939 | SIGNOR-169225 |
| LRRK2 | phosphorylation up-regulates → | ARHGEF7 PThr127 | phosphorylation up-regulates → | ARHGEF7 | 21048939 | SIGNOR-169221 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCG | phosphorylation → up-regulates | ARHGEF7 | SIGNOR-205234 |
| PRKCG | phosphorylation → up-regulates | ARHGEF7 | SIGNOR-205238 |
| LRRK2 | phosphorylation → up-regulates | ARHGEF7 | SIGNOR-169225 |
| LRRK2 | phosphorylation → up-regulates | ARHGEF7 | SIGNOR-169221 |