| Name | IKBKE |
| ID | Q14164 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 9-315 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKE | CDK2AP1 | Ser46 | LSDYGPPsLGYTQGT | phosphorylation unknown | 22427660 | SIGNOR-264780 |
| IKBKE | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 23691078 | SIGNOR-202054 |
| IKBKE | TRAF3IP2 | Ser328 | KVILNYPsPWDHEER | phosphorylation up-regulates activity | 21822257 | SIGNOR-262883 |
| IKBKE | NFATC1 | Ser151 | VLPSSKRsPSTATLS | phosphorylation up-regulates activity | 31730483 | SIGNOR-276778 |
| IKBKE | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 19940156 | SIGNOR-161834 |
| IKBKE | JUN | – | phosphorylation up-regulates activity | 22384232 | SIGNOR-279621 | |
| IKBKE | IRF1 | Ser215 | DLYNFQVsPMPSTSE | phosphorylation down-regulates activity | 24396068 | SIGNOR-276480 |
| IKBKE | IRF1 | Ser219 | FQVSPMPsTSEATTD | phosphorylation down-regulates activity | 24396068 | SIGNOR-276478 |
| IKBKE | IRF1 | Ser221 | VSPMPSTsEATTDED | phosphorylation down-regulates activity | 24396068 | SIGNOR-276479 |
| IKBKE | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 11815618 | SIGNOR-249367 |
| IKBKE | NFKBIA | – | phosphorylation down-regulates quantity by destabilization | 20717897 | SIGNOR-167524 | |
| IKBKE | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates | 17502367 | SIGNOR-154775 |
| IKBKE | YAP1 | Ser419 | TPDDFLNsVDEMDTG | phosphorylation down-regulates quantity by destabilization | 28481329 | SIGNOR-277355 |
| IKBKE | RELA | Ser468 | AVFTDLAsVDNSEFQ | phosphorylation up-regulates | 15489227 | SIGNOR-129939 |
| IKBKE | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates | 15489227 | SIGNOR-129943 |
| IKBKE | REL | – | phosphorylation up-regulates | 16888014 | SIGNOR-148620 | |
| IKBKE | TRAF2 | Ser11 | ASVTPPGsLELLQPG | phosphorylation up-regulates activity | 24362534 | SIGNOR-279195 |
| IKBKE | PDE3B | – | phosphorylation up-regulates activity | 29425491 | SIGNOR-278517 | |
| IKBKE | IKBKE | Thr501 | ELRSRLRtLAEVLSR | phosphorylation up-regulates activity | 24882218 | SIGNOR-276637 |
| IKBKE | IRF3 | Ser385 | MARVGGAsSLENTVD | phosphorylation up-regulates activity | 18440553 | SIGNOR-178363 |
| IKBKE | IRF3 | Ser386 | ARVGGASsLENTVDL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178367 |
| IKBKE | IRF3 | Ser396 | NTVDLHIsNSHPLSL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178371 |
| IKBKE | IRF3 | Ser398 | VDLHISNsHPLSLTS | phosphorylation up-regulates activity | 18440553 | SIGNOR-178375 |
| IKBKE | IRF3 | Ser402 | ISNSHPLsLTSDQYK | phosphorylation up-regulates activity | 18440553 | SIGNOR-178379 |
| IKBKE | IRF3 | Ser405 | SHPLSLTsDQYKAYL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178383 |
| IKBKE | IRF3 | Thr404 | NSHPLSLtSDQYKAY | phosphorylation up-regulates activity | 18440553 | SIGNOR-178387 |
| IKBKE | TANK | Ser100 | QPQDKVIsGIAREKL | phosphorylation down-regulates activity | 10759890 | SIGNOR-262713 |
| IKBKE | TANK | Ser126 | RKETSARsLGSPLLH | phosphorylation down-regulates activity | 10759890 | SIGNOR-262715 |
| IKBKE | TANK | Ser178 | TATETQCsVPIQCTD | phosphorylation down-regulates activity | 10759890 | SIGNOR-262716 |
| IKBKE | TANK | Ser208 | DINRGAPsITSVTPR | phosphorylation down-regulates activity | 10759890 | SIGNOR-262717 |
| IKBKE | TANK | Ser228 | EEDTSFEsLSKFNVK | phosphorylation down-regulates activity | 10759890 | SIGNOR-262718 |
| IKBKE | TANK | Ser257 | PERPGILsPATSEAV | phosphorylation down-regulates activity | 10759890 | SIGNOR-262719 |
| IKBKE | TANK | Ser406 | CQAVFPPsITSRGDF | phosphorylation down-regulates activity | 10759890 | SIGNOR-262720 |
| IKBKE | TANK | Ser409 | VFPPSITsRGDFLRH | phosphorylation down-regulates activity | 10759890 | SIGNOR-262721 |
| IKBKE | TANK | Ser49 | REQQEQLsLQQTIID | phosphorylation down-regulates activity | 10759890 | SIGNOR-262722 |
| IKBKE | IRF7 | Ser471 | GTQREGVsSLDSSSL | phosphorylation up-regulates | 10893229 | SIGNOR-79139 |
| IKBKE | IRF7 | Ser472 | TQREGVSsLDSSSLS | phosphorylation up-regulates | 10893229 | SIGNOR-79143 |
| IKBKE | PBXIP1 | Ser147 | REEGRCSsSDDDTDV | phosphorylation down-regulates quantity by destabilization | 24488098 | SIGNOR-276618 |
| IKBKE | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 19481526 | SIGNOR-278311 |
| IKBKE | FAF1 | Ser556 | EREAIRLsLEQALPP | phosphorylation down-regulates quantity by destabilization | 30472208 | SIGNOR-277618 |
| IKBKE | NfKb-p65/p50 | – | phosphorylation up-regulates activity | 15489227 | SIGNOR-217379 | |
| IKBKE | REL/RELA | – | phosphorylation up-regulates | 16888014 | SIGNOR-217664 | |
| IKBKE | FOXO | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 23691078 | SIGNOR-252949 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKE | phosphorylation up-regulates → | CDK2AP1 PSer46 | phosphorylation down-regulates ⊣ | CDK2AP1 | 22427660 | SIGNOR-264780 |
| IKBKE | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 23691078 | SIGNOR-202054 |
| IKBKE | phosphorylation up-regulates → | TRAF3IP2 PSer328 | phosphorylation up-regulates → | TRAF3IP2 | 21822257 | SIGNOR-262883 |
| IKBKE | phosphorylation up-regulates → | NFATC1 PSer151 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276778 |
| IKBKE | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 19940156 | SIGNOR-161834 |
| IKBKE | phosphorylation up-regulates → | IRF1 PSer215 | phosphorylation down-regulates ⊣ | IRF1 | 24396068 | SIGNOR-276480 |
| IKBKE | phosphorylation up-regulates → | IRF1 PSer219 | phosphorylation down-regulates ⊣ | IRF1 | 24396068 | SIGNOR-276478 |
| IKBKE | phosphorylation up-regulates → | IRF1 PSer221 | phosphorylation down-regulates ⊣ | IRF1 | 24396068 | SIGNOR-276479 |
| IKBKE | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 11815618 | SIGNOR-249367 |
| IKBKE | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154775 |
| IKBKE | phosphorylation up-regulates → | YAP1 PSer419 | phosphorylation down-regulates ⊣ | YAP1 | 28481329 | SIGNOR-277355 |
| IKBKE | phosphorylation up-regulates → | RELA PSer468 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129939 |
| IKBKE | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129943 |
| IKBKE | phosphorylation up-regulates → | TRAF2 PSer11 | phosphorylation up-regulates → | TRAF2 | 24362534 | SIGNOR-279195 |
| IKBKE | phosphorylation up-regulates → | IKBKE PThr501 | phosphorylation up-regulates → | IKBKE | 24882218 | SIGNOR-276637 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer385 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178363 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer386 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178367 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer396 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178371 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer398 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178375 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer402 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178379 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer405 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178383 |
| IKBKE | phosphorylation up-regulates → | IRF3 PThr404 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178387 |
| IKBKE | phosphorylation up-regulates → | TANK PSer100 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262713 |
| IKBKE | phosphorylation up-regulates → | TANK PSer126 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262715 |
| IKBKE | phosphorylation up-regulates → | TANK PSer178 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262716 |
| IKBKE | phosphorylation up-regulates → | TANK PSer208 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262717 |
| IKBKE | phosphorylation up-regulates → | TANK PSer228 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262718 |
| IKBKE | phosphorylation up-regulates → | TANK PSer257 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262719 |
| IKBKE | phosphorylation up-regulates → | TANK PSer406 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262720 |
| IKBKE | phosphorylation up-regulates → | TANK PSer409 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262721 |
| IKBKE | phosphorylation up-regulates → | TANK PSer49 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262722 |
| IKBKE | phosphorylation up-regulates → | IRF7 PSer471 | phosphorylation up-regulates → | IRF7 | 10893229 | SIGNOR-79139 |
| IKBKE | phosphorylation up-regulates → | IRF7 PSer472 | phosphorylation up-regulates → | IRF7 | 10893229 | SIGNOR-79143 |
| IKBKE | phosphorylation up-regulates → | PBXIP1 PSer147 | phosphorylation down-regulates ⊣ | PBXIP1 | 24488098 | SIGNOR-276618 |
| IKBKE | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 19481526 | SIGNOR-278311 |
| IKBKE | phosphorylation up-regulates → | FAF1 PSer556 | phosphorylation down-regulates ⊣ | FAF1 | 30472208 | SIGNOR-277618 |
| IKBKE | phosphorylation up-regulates → | FOXO PSer644 | phosphorylation down-regulates ⊣ | FOXO | 23691078 | SIGNOR-252949 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKE | phosphorylation → unknown | CDK2AP1 | SIGNOR-264780 |
| IKBKE | phosphorylation down-regulates | FOXO3 | SIGNOR-202054 |
| IKBKE | phosphorylation → up-regulates activity | TRAF3IP2 | SIGNOR-262883 |
| IKBKE | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276778 |
| IKBKE | phosphorylation → up-regulates | ESR1 | SIGNOR-161834 |
| IKBKE | phosphorylation → up-regulates activity | JUN | SIGNOR-279621 |
| IKBKE | phosphorylation → down-regulates activity | IRF1 | SIGNOR-276480 |
| IKBKE | phosphorylation → down-regulates activity | IRF1 | SIGNOR-276478 |
| IKBKE | phosphorylation → down-regulates activity | IRF1 | SIGNOR-276479 |
| IKBKE | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249367 |
| IKBKE | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-167524 |
| IKBKE | phosphorylation → up-regulates | STAT1 | SIGNOR-154775 |
| IKBKE | phosphorylation down-regulates quantity by destabilization | YAP1 | SIGNOR-277355 |
| IKBKE | phosphorylation → up-regulates | RELA | SIGNOR-129939 |
| IKBKE | phosphorylation → up-regulates | RELA | SIGNOR-129943 |
| IKBKE | phosphorylation → up-regulates | REL | SIGNOR-148620 |
| IKBKE | phosphorylation → up-regulates activity | TRAF2 | SIGNOR-279195 |
| IKBKE | phosphorylation → up-regulates activity | PDE3B | SIGNOR-278517 |
| IKBKE | phosphorylation → up-regulates activity | IKBKE | SIGNOR-276637 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178363 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178367 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178371 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178375 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178379 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178383 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178387 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262713 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262715 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262716 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262717 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262718 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262719 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262720 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262721 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262722 |
| IKBKE | phosphorylation → up-regulates | IRF7 | SIGNOR-79139 |
| IKBKE | phosphorylation → up-regulates | IRF7 | SIGNOR-79143 |
| IKBKE | phosphorylation down-regulates quantity by destabilization | PBXIP1 | SIGNOR-276618 |
| IKBKE | phosphorylation → down-regulates activity | CYLD | SIGNOR-278311 |
| IKBKE | phosphorylation down-regulates quantity by destabilization | FAF1 | SIGNOR-277618 |
| IKBKE | phosphorylation → up-regulates activity | NfKb-p65/p50 | SIGNOR-217379 |
| IKBKE | phosphorylation → up-regulates | REL/RELA | SIGNOR-217664 |
| IKBKE | phosphorylation down-regulates | FOXO | SIGNOR-252949 |