Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PPM1A	IKBKE	Ser172	DDDEKFVsVYGTEEY	dephosphorylation down-regulates activity	27419230	SIGNOR-277072
EGFR	IKBKE	Tyr153	GEEGQSIyKLTDFGA	phosphorylation up-regulates activity	27287717	SIGNOR-278223
EGFR	IKBKE	Tyr153	GEEGQSIyKLTDFGA	phosphorylation up-regulates activity	27287717	SIGNOR-277242
EGFR	IKBKE	Tyr179	SVYGTEEyLHPDMYE	phosphorylation up-regulates activity	27287717	SIGNOR-277243
IKBKE	IKBKE	Thr501	ELRSRLRtLAEVLSR	phosphorylation up-regulates activity	24882218	SIGNOR-276637
EGFR	IKBKE	Tyr179	SVYGTEEyLHPDMYE	phosphorylation up-regulates activity	27287717	SIGNOR-278222

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PPM1A	dephosphorylation down-regulates ⊣	IKBKE PSer172	dephosphorylation up-regulates →	IKBKE	27419230	SIGNOR-277072
EGFR	phosphorylation up-regulates →	IKBKE PTyr153	phosphorylation up-regulates →	IKBKE	27287717	SIGNOR-278223
EGFR	phosphorylation up-regulates →	IKBKE PTyr153	phosphorylation up-regulates →	IKBKE	27287717	SIGNOR-277242
EGFR	phosphorylation up-regulates →	IKBKE PTyr179	phosphorylation up-regulates →	IKBKE	27287717	SIGNOR-277243
IKBKE	phosphorylation up-regulates →	IKBKE PThr501	phosphorylation up-regulates →	IKBKE	24882218	SIGNOR-276637
EGFR	phosphorylation up-regulates →	IKBKE PTyr179	phosphorylation up-regulates →	IKBKE	27287717	SIGNOR-278222

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PPM1A	dephosphorylation → down-regulates activity	IKBKE	SIGNOR-277072
EGFR	phosphorylation → up-regulates activity	IKBKE	SIGNOR-278223
EGFR	phosphorylation → up-regulates activity	IKBKE	SIGNOR-277242
EGFR	phosphorylation → up-regulates activity	IKBKE	SIGNOR-277243
IKBKE	phosphorylation → up-regulates activity	IKBKE	SIGNOR-276637
EGFR	phosphorylation → up-regulates activity	IKBKE	SIGNOR-278222