| Name | DOCK1 |
| ID | Q14185 |
| Role | substrate |
| Enzymatic Domains |
SH3 9-70 PROSITE-ProRule
C2 DOCK-type 425-609 PROSITE-ProRule
DOCKER 1207-1617 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | DOCK1 | Thr1772 | QQTPPPVtPRAKLSF | phosphorylation unknown | 22028470 | SIGNOR-262769 |
| EGFR | DOCK1 | Ser1250 | HAKLLKWsEDVCVAH | phosphorylation up-regulates activity | 23728337 | SIGNOR-279329 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | DOCK1 PThr1772 | phosphorylation down-regulates ⊣ | DOCK1 | 22028470 | SIGNOR-262769 |
| EGFR | phosphorylation up-regulates → | DOCK1 PSer1250 | phosphorylation up-regulates → | DOCK1 | 23728337 | SIGNOR-279329 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → unknown | DOCK1 | SIGNOR-262769 |
| EGFR | phosphorylation → up-regulates activity | DOCK1 | SIGNOR-279329 |