| Name | WRN |
| ID | Q14191 |
| Role | substrate |
| Enzymatic Domains |
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Helicase ATP-binding 558-724 PROSITE-ProRule
Helicase C-terminal 749-899 PROSITE-ProRule
HRDC 1150-1229 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | WRN | Ser467 | DTSYVIEsDEDLEME | phosphorylation up-regulates | 24429382 | SIGNOR-203741 |
| PRKDC | WRN | Ser440 | DTSYVIEsDEDLEME | phosphorylation up-regulates | 24429382 | SIGNOR-203737 |
| ATR | WRN | Ser1141 | PEKAYSSsQPVISAQ | phosphorylation down-regulates quantity | 26695548 | SIGNOR-278159 |
| ABL1 | WRN | – | phosphorylation up-regulates | 12944467 | SIGNOR-86497 | |
| ATR | WRN | Ser1141 | PEKAYSSsQPVISAQ | phosphorylation down-regulates quantity by destabilization | 26695548 | SIGNOR-277187 |
| ATM | WRN | Ser1141 | PEKAYSSsQPVISAQ | phosphorylation unknown | 10608806 | SIGNOR-250577 |
| ATM | WRN | Ser1292 | MTIGMHLsQAVKAGC | phosphorylation unknown | 10608806 | SIGNOR-250578 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | phosphorylation up-regulates → | WRN PSer467 | phosphorylation up-regulates → | WRN | 24429382 | SIGNOR-203741 |
| PRKDC | phosphorylation up-regulates → | WRN PSer440 | phosphorylation up-regulates → | WRN | 24429382 | SIGNOR-203737 |
| ATR | phosphorylation up-regulates → | WRN PSer1141 | phosphorylation down-regulates ⊣ | WRN | 26695548 | SIGNOR-278159 |
| ATR | phosphorylation up-regulates → | WRN PSer1141 | phosphorylation down-regulates ⊣ | WRN | 26695548 | SIGNOR-277187 |
| ATM | phosphorylation up-regulates → | WRN PSer1141 | phosphorylation down-regulates ⊣ | WRN | 10608806 | SIGNOR-250577 |
| ATM | phosphorylation up-regulates → | WRN PSer1292 | phosphorylation down-regulates ⊣ | WRN | 10608806 | SIGNOR-250578 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKDC | phosphorylation → up-regulates | WRN | SIGNOR-203741 |
| PRKDC | phosphorylation → up-regulates | WRN | SIGNOR-203737 |
| ATR | phosphorylation → down-regulates quantity | WRN | SIGNOR-278159 |
| ABL1 | phosphorylation → up-regulates | WRN | SIGNOR-86497 |
| ATR | phosphorylation down-regulates quantity by destabilization | WRN | SIGNOR-277187 |
| ATM | phosphorylation → unknown | WRN | SIGNOR-250577 |
| ATM | phosphorylation → unknown | WRN | SIGNOR-250578 |