| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | WRN | Ser1141 | PEKAYSSsQPVISAQ | phosphorylation down-regulates quantity | 26695548 | SIGNOR-278159 |
| ATR | WRN | Ser1141 | PEKAYSSsQPVISAQ | phosphorylation down-regulates quantity by destabilization | 26695548 | SIGNOR-277187 |
| ATM | WRN | Ser1141 | PEKAYSSsQPVISAQ | phosphorylation unknown | 10608806 | SIGNOR-250577 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | phosphorylation up-regulates → | WRN PSer1141 | phosphorylation down-regulates ⊣ | WRN | 26695548 | SIGNOR-278159 |
| ATR | phosphorylation up-regulates → | WRN PSer1141 | phosphorylation down-regulates ⊣ | WRN | 26695548 | SIGNOR-277187 |
| ATM | phosphorylation up-regulates → | WRN PSer1141 | phosphorylation down-regulates ⊣ | WRN | 10608806 | SIGNOR-250577 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATR | phosphorylation → down-regulates quantity | WRN | SIGNOR-278159 |
| ATR | phosphorylation down-regulates quantity by destabilization | WRN | SIGNOR-277187 |
| ATM | phosphorylation → unknown | WRN | SIGNOR-250577 |
