| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | DPYSL3 | Thr514 | TTTPKGGtPAGSARG | phosphorylation up-regulates activity | 16611631 | SIGNOR-145987 |
| CDK5 | DPYSL3 | Thr509 | PVFDLTTtPKGGTPA | phosphorylation up-regulates activity | 16611631 | SIGNOR-145967 |
| GSK3B | DPYSL3 | Thr509 | PVFDLTTtPKGGTPA | phosphorylation up-regulates activity | 16611631 | SIGNOR-146011 |
| GSK3B | DPYSL3 | Ser518 | KGGTPAGsARGSPTR | phosphorylation up-regulates activity | 16611631 | SIGNOR-146003 |
| GSK3B | DPYSL3 | Ser522 | PAGSARGsPTRPNPP | phosphorylation down-regulates activity | 16611631 | SIGNOR-146007 |
| DYRK2 | DPYSL3 | Ser518 | KGGTPAGsARGSPTR | phosphorylation up-regulates activity | 16611631 | SIGNOR-145975 |
| DYRK2 | DPYSL3 | Thr509 | PVFDLTTtPKGGTPA | phosphorylation up-regulates activity | 16611631 | SIGNOR-145979 |
| CDK5 | DPYSL3 | Thr514 | TTTPKGGtPAGSARG | phosphorylation up-regulates activity | 16611631 | SIGNOR-145971 |
| GSK3B | DPYSL3 | Thr514 | TTTPKGGtPAGSARG | phosphorylation up-regulates activity | 16611631 | SIGNOR-146015 |
| CDK5 | DPYSL3 | Ser518 | KGGTPAGsARGSPTR | phosphorylation up-regulates activity | 16611631 | SIGNOR-145963 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | phosphorylation up-regulates → | DPYSL3 PThr514 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145987 |
| CDK5 | phosphorylation up-regulates → | DPYSL3 PThr509 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145967 |
| GSK3B | phosphorylation up-regulates → | DPYSL3 PThr509 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-146011 |
| GSK3B | phosphorylation up-regulates → | DPYSL3 PSer518 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-146003 |
| GSK3B | phosphorylation up-regulates → | DPYSL3 PSer522 | phosphorylation down-regulates ⊣ | DPYSL3 | 16611631 | SIGNOR-146007 |
| DYRK2 | phosphorylation up-regulates → | DPYSL3 PSer518 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145975 |
| DYRK2 | phosphorylation up-regulates → | DPYSL3 PThr509 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145979 |
| CDK5 | phosphorylation up-regulates → | DPYSL3 PThr514 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145971 |
| GSK3B | phosphorylation up-regulates → | DPYSL3 PThr514 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-146015 |
| CDK5 | phosphorylation up-regulates → | DPYSL3 PSer518 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145963 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK2 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145987 |
| CDK5 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145967 |
| GSK3B | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-146011 |
| GSK3B | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-146003 |
| GSK3B | phosphorylation → down-regulates activity | DPYSL3 | SIGNOR-146007 |
| DYRK2 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145975 |
| DYRK2 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145979 |
| CDK5 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145971 |
| GSK3B | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-146015 |
| CDK5 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145963 |
