| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | BECN1 | Ser90 | IPPARMMsTESANSF | phosphorylation up-regulates activity | 32187724 | SIGNOR-264557 |
| MAPKAPK3 | BECN1 | Ser90 | IPPARMMsTESANSF | phosphorylation up-regulates activity | 25693418 | SIGNOR-279342 |
| ROCK1 | BECN1 | Thr119 | LSRRLKVtGDLFDIM | phosphorylation up-regulates activity | 23877263 | SIGNOR-278198 |
| AKT1 | BECN1 | Ser295 | FRLGRLPsVPVEWNE | phosphorylation down-regulates activity | 31852899 | SIGNOR-279667 |
| STK4 | BECN1 | Thr108 | GEASDGGtMENLSRR | phosphorylation up-regulates activity | 24141421 | SIGNOR-278502 |
| CHEK2 | BECN1 | Ser93 | ARMMSTEsANSFTLI | phosphorylation up-regulates activity | 32187724 | SIGNOR-264556 |
| JAK2 | BECN1 | Tyr333 | QRYRLVPyGNHSYLE | phosphorylation up-regulates activity | 34131122 | SIGNOR-277567 |
| DAPK1 | BECN1 | Thr119 | LSRRLKVtGDLFDIM | phosphorylation up-regulates | 19180116 | SIGNOR-183548 |
| JAK2 | BECN1 | Tyr333 | QRYRLVPyGNHSYLE | phosphorylation up-regulates quantity | 34131122 | SIGNOR-278312 |
| MAPKAPK2 | BECN1 | Ser90 | IPPARMMsTESANSF | phosphorylation up-regulates activity | 25693418 | SIGNOR-278342 |
| EGFR | BECN1 | Tyr233 | EAQYQREySEFKRQQ | phosphorylation down-regulates activity | 24034250 | SIGNOR-278357 |
| AKT1 | BECN1 | Ser234 | AQYQREYsEFKRQQL | phosphorylation down-regulates activity | 31852899 | SIGNOR-279666 |
| STYK1 | BECN1 | Ser90 | IPPARMMsTESANSF | phosphorylation up-regulates activity | 31696776 | SIGNOR-264568 |
| ULK1 | BECN1 | – | phosphorylation up-regulates activity | 29671878 | SIGNOR-278503 | |
| DAPK1 | BECN1 | Thr119 | LSRRLKVtGDLFDIM | phosphorylation up-regulates | 19395874 | SIGNOR-185589 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | BECN1 PSer90 | phosphorylation up-regulates → | BECN1 | 32187724 | SIGNOR-264557 |
| MAPKAPK3 | phosphorylation up-regulates → | BECN1 PSer90 | phosphorylation up-regulates → | BECN1 | 25693418 | SIGNOR-279342 |
| ROCK1 | phosphorylation up-regulates → | BECN1 PThr119 | phosphorylation up-regulates → | BECN1 | 23877263 | SIGNOR-278198 |
| AKT1 | phosphorylation up-regulates → | BECN1 PSer295 | phosphorylation down-regulates ⊣ | BECN1 | 31852899 | SIGNOR-279667 |
| STK4 | phosphorylation up-regulates → | BECN1 PThr108 | phosphorylation up-regulates → | BECN1 | 24141421 | SIGNOR-278502 |
| CHEK2 | phosphorylation up-regulates → | BECN1 PSer93 | phosphorylation up-regulates → | BECN1 | 32187724 | SIGNOR-264556 |
| JAK2 | phosphorylation up-regulates → | BECN1 PTyr333 | phosphorylation up-regulates → | BECN1 | 34131122 | SIGNOR-277567 |
| DAPK1 | phosphorylation up-regulates → | BECN1 PThr119 | phosphorylation up-regulates → | BECN1 | 19180116 | SIGNOR-183548 |
| JAK2 | phosphorylation up-regulates → | BECN1 PTyr333 | phosphorylation up-regulates → | BECN1 | 34131122 | SIGNOR-278312 |
| MAPKAPK2 | phosphorylation up-regulates → | BECN1 PSer90 | phosphorylation up-regulates → | BECN1 | 25693418 | SIGNOR-278342 |
| EGFR | phosphorylation up-regulates → | BECN1 PTyr233 | phosphorylation down-regulates ⊣ | BECN1 | 24034250 | SIGNOR-278357 |
| AKT1 | phosphorylation up-regulates → | BECN1 PSer234 | phosphorylation down-regulates ⊣ | BECN1 | 31852899 | SIGNOR-279666 |
| STYK1 | phosphorylation up-regulates → | BECN1 PSer90 | phosphorylation up-regulates → | BECN1 | 31696776 | SIGNOR-264568 |
| DAPK1 | phosphorylation up-regulates → | BECN1 PThr119 | phosphorylation up-regulates → | BECN1 | 19395874 | SIGNOR-185589 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-264557 |
| MAPKAPK3 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-279342 |
| ROCK1 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-278198 |
| AKT1 | phosphorylation → down-regulates activity | BECN1 | SIGNOR-279667 |
| STK4 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-278502 |
| CHEK2 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-264556 |
| JAK2 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-277567 |
| DAPK1 | phosphorylation → up-regulates | BECN1 | SIGNOR-183548 |
| JAK2 | phosphorylation → up-regulates quantity | BECN1 | SIGNOR-278312 |
| MAPKAPK2 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-278342 |
| EGFR | phosphorylation → down-regulates activity | BECN1 | SIGNOR-278357 |
| AKT1 | phosphorylation → down-regulates activity | BECN1 | SIGNOR-279666 |
| STYK1 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-264568 |
| ULK1 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-278503 |
| DAPK1 | phosphorylation → up-regulates | BECN1 | SIGNOR-185589 |
