| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DAPK1 | BECN1 | Thr119 | LSRRLKVtGDLFDIM | phosphorylation up-regulates | 19395874 | SIGNOR-185589 |
| ROCK1 | BECN1 | Thr119 | LSRRLKVtGDLFDIM | phosphorylation up-regulates activity | 23877263 | SIGNOR-278198 |
| DAPK1 | BECN1 | Thr119 | LSRRLKVtGDLFDIM | phosphorylation up-regulates | 19180116 | SIGNOR-183548 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DAPK1 | phosphorylation up-regulates → | BECN1 PThr119 | phosphorylation up-regulates → | BECN1 | 19395874 | SIGNOR-185589 |
| ROCK1 | phosphorylation up-regulates → | BECN1 PThr119 | phosphorylation up-regulates → | BECN1 | 23877263 | SIGNOR-278198 |
| DAPK1 | phosphorylation up-regulates → | BECN1 PThr119 | phosphorylation up-regulates → | BECN1 | 19180116 | SIGNOR-183548 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DAPK1 | phosphorylation → up-regulates | BECN1 | SIGNOR-185589 |
| ROCK1 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-278198 |
| DAPK1 | phosphorylation → up-regulates | BECN1 | SIGNOR-183548 |
