Entity Details

Name HES1
ID Q14469
Role substrate
Enzymatic Domains
bHLH 34-91
PROSITE-ProRule
Orange 110-143
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ALKHES1–phosphorylation
up-regulates activity		35640677SIGNOR-280181
PRKCAHES1Ser37TASEHRKsSKPIMEKphosphorylation
down-regulates activity		9389649SIGNOR-248992
PRKCAHES1Ser38ASEHRKSsKPIMEKRphosphorylation
down-regulates activity		9389649SIGNOR-248993
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCAphosphorylation
up-regulates
→
HES1
PSer37		phosphorylation
down-regulates
⊣		HES19389649SIGNOR-248992
PRKCAphosphorylation
up-regulates
→
HES1
PSer38		phosphorylation
down-regulates
⊣		HES19389649SIGNOR-248993
Regulator Mechanism/Effect Target SIGNOR-ID
ALKphosphorylation
→
up-regulates activity 		HES1SIGNOR-280181
PRKCAphosphorylation
→
down-regulates activity 		HES1SIGNOR-248992
PRKCAphosphorylation
→
down-regulates activity 		HES1SIGNOR-248993