| Name | SCN5A |
| ID | Q14524 |
| Role | substrate |
| Enzymatic Domains |
IQ 1901-1930 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | SCN5A | Ser525 | TSMKPRSsRGSIFTF | phosphorylation up-regulates activity | 33410863 | SIGNOR-275766 |
| PKA | SCN5A | Ser528 | KPRSSRGsIFTFRRR | phosphorylation up-regulates activity | 12242273 | SIGNOR-275992 |
| SGK3 | SCN5A | Ser664 | GARQRALsAVSVLTS | phosphorylation up-regulates activity | 33410863 | SIGNOR-275768 |
| CAMK2A | SCN5A | Ser571 | PWPLRRTsAQGQPSP | phosphorylation up-regulates activity | 33410863 | SIGNOR-275771 |
| CAMK2D | SCN5A | Ser1934 | LFRQQAGsGLSEEDA | phosphorylation up-regulates activity | 28882890 | SIGNOR-275782 |
| AMPK | SCN5A | Thr101 | IVLNKGKtIFRFSAT | phosphorylation up-regulates activity | 33410863 | SIGNOR-275769 |
| CAMK2A | SCN5A | Ser516 | LSLTRGLsRTSMKPR | phosphorylation up-regulates activity | 33410863 | SIGNOR-275770 |
| CAMK2G | SCN5A | Ser571 | PWPLRRTsAQGQPSP | phosphorylation up-regulates activity | 33410863 | SIGNOR-275780 |
| CAMK2D | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation down-regulates | 22514276 | SIGNOR-197067 |
| SGK3 | SCN5A | Ser484 | KRRKRMSsGTEECGE | phosphorylation up-regulates activity | 33410863 | SIGNOR-275767 |
| CAMK2D | SCN5A | Ser516 | LSLTRGLsRTSMKPR | phosphorylation down-regulates | 22514276 | SIGNOR-197058 |
| CAMK2A | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275772 |
| PKA | SCN5A | Ser525 | TSMKPRSsRGSIFTF | phosphorylation up-regulates activity | 12242273 | SIGNOR-275991 |
| CAMK2D | SCN5A | Ser571 | PWPLRRTsAQGQPSP | phosphorylation up-regulates activity | 33410863 | SIGNOR-275777 |
| CAMK2D | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275778 |
| CAMK2B | SCN5A | Ser516 | LSLTRGLsRTSMKPR | phosphorylation up-regulates activity | 33410863 | SIGNOR-275773 |
| CAMK2B | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275775 |
| PKA | SCN5A | Ser36 | AEKQARGsTTLQESR | phosphorylation up-regulates activity | 33410863 | SIGNOR-275765 |
| PKA | SCN5A | Ser528 | KPRSSRGsIFTFRRR | phosphorylation up-regulates activity | 33410863 | SIGNOR-275764 |
| CAMK2D | SCN5A | Ser516 | LSLTRGLsRTSMKPR | phosphorylation up-regulates activity | 33410863 | SIGNOR-275776 |
| CAMK2B | SCN5A | Ser571 | PWPLRRTsAQGQPSP | phosphorylation up-regulates activity | 33410863 | SIGNOR-275774 |
| CAMK2G | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275781 |
| CAMK2G | SCN5A | Ser516 | LSLTRGLsRTSMKPR | phosphorylation up-regulates activity | 33410863 | SIGNOR-275779 |
| CAMK2D | SCN5A | Ser1985 | DSVTRATsDNLQVRG | phosphorylation up-regulates activity | 28882890 | SIGNOR-275783 |
| PRKAA1 | SCN5A | Thr101 | IVLNKGKtIFRFSAT | phosphorylation down-regulates quantity by destabilization | 30759345 | SIGNOR-277432 |
| FYN | SCN5A | Tyr1495 | TEEQKKYyNAMKKLG | phosphorylation down-regulates | 15831816 | SIGNOR-135600 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | SCN5A PSer525 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275766 |
| PKA | phosphorylation up-regulates → | SCN5A PSer528 | phosphorylation up-regulates → | SCN5A | 12242273 | SIGNOR-275992 |
| SGK3 | phosphorylation up-regulates → | SCN5A PSer664 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275768 |
| CAMK2A | phosphorylation up-regulates → | SCN5A PSer571 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275771 |
| CAMK2D | phosphorylation up-regulates → | SCN5A PSer1934 | phosphorylation up-regulates → | SCN5A | 28882890 | SIGNOR-275782 |
| AMPK | phosphorylation up-regulates → | SCN5A PThr101 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275769 |
| CAMK2A | phosphorylation up-regulates → | SCN5A PSer516 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275770 |
| CAMK2G | phosphorylation up-regulates → | SCN5A PSer571 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275780 |
| CAMK2D | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation down-regulates ⊣ | SCN5A | 22514276 | SIGNOR-197067 |
| SGK3 | phosphorylation up-regulates → | SCN5A PSer484 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275767 |
| CAMK2D | phosphorylation up-regulates → | SCN5A PSer516 | phosphorylation down-regulates ⊣ | SCN5A | 22514276 | SIGNOR-197058 |
| CAMK2A | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275772 |
| PKA | phosphorylation up-regulates → | SCN5A PSer525 | phosphorylation up-regulates → | SCN5A | 12242273 | SIGNOR-275991 |
| CAMK2D | phosphorylation up-regulates → | SCN5A PSer571 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275777 |
| CAMK2D | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275778 |
| CAMK2B | phosphorylation up-regulates → | SCN5A PSer516 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275773 |
| CAMK2B | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275775 |
| PKA | phosphorylation up-regulates → | SCN5A PSer36 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275765 |
| PKA | phosphorylation up-regulates → | SCN5A PSer528 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275764 |
| CAMK2D | phosphorylation up-regulates → | SCN5A PSer516 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275776 |
| CAMK2B | phosphorylation up-regulates → | SCN5A PSer571 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275774 |
| CAMK2G | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275781 |
| CAMK2G | phosphorylation up-regulates → | SCN5A PSer516 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275779 |
| CAMK2D | phosphorylation up-regulates → | SCN5A PSer1985 | phosphorylation up-regulates → | SCN5A | 28882890 | SIGNOR-275783 |
| PRKAA1 | phosphorylation up-regulates → | SCN5A PThr101 | phosphorylation down-regulates ⊣ | SCN5A | 30759345 | SIGNOR-277432 |
| FYN | phosphorylation up-regulates → | SCN5A PTyr1495 | phosphorylation down-regulates ⊣ | SCN5A | 15831816 | SIGNOR-135600 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275766 |
| PKA | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275992 |
| SGK3 | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275768 |
| CAMK2A | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275771 |
| CAMK2D | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275782 |
| AMPK | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275769 |
| CAMK2A | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275770 |
| CAMK2G | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275780 |
| CAMK2D | phosphorylation down-regulates | SCN5A | SIGNOR-197067 |
| SGK3 | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275767 |
| CAMK2D | phosphorylation down-regulates | SCN5A | SIGNOR-197058 |
| CAMK2A | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275772 |
| PKA | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275991 |
| CAMK2D | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275777 |
| CAMK2D | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275778 |
| CAMK2B | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275773 |
| CAMK2B | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275775 |
| PKA | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275765 |
| PKA | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275764 |
| CAMK2D | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275776 |
| CAMK2B | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275774 |
| CAMK2G | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275781 |
| CAMK2G | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275779 |
| CAMK2D | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275783 |
| PRKAA1 | phosphorylation down-regulates quantity by destabilization | SCN5A | SIGNOR-277432 |
| FYN | phosphorylation down-regulates | SCN5A | SIGNOR-135600 |