| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | SCN5A | Thr101 | IVLNKGKtIFRFSAT | phosphorylation down-regulates quantity by destabilization | 30759345 | SIGNOR-277432 |
| AMPK | SCN5A | Thr101 | IVLNKGKtIFRFSAT | phosphorylation up-regulates activity | 33410863 | SIGNOR-275769 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | phosphorylation up-regulates → | SCN5A PThr101 | phosphorylation down-regulates ⊣ | SCN5A | 30759345 | SIGNOR-277432 |
| AMPK | phosphorylation up-regulates → | SCN5A PThr101 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275769 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA1 | phosphorylation![]() down-regulates quantity by destabilization | SCN5A | SIGNOR-277432 |
| AMPK | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275769 |