| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2D | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation down-regulates | 22514276 | SIGNOR-197067 |
| CAMK2A | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275772 |
| CAMK2D | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275778 |
| CAMK2B | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275775 |
| CAMK2G | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275781 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2D | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation down-regulates ⊣ | SCN5A | 22514276 | SIGNOR-197067 |
| CAMK2A | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275772 |
| CAMK2D | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275778 |
| CAMK2B | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275775 |
| CAMK2G | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275781 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2D | phosphorylation down-regulates | SCN5A | SIGNOR-197067 |
| CAMK2A | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275772 |
| CAMK2D | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275778 |
| CAMK2B | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275775 |
| CAMK2G | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275781 |
