| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | IRF3 | Ser396 | NTVDLHIsNSHPLSL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178399 |
| IKBKE | IRF3 | Ser386 | ARVGGASsLENTVDL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178367 |
| PPP2CA | IRF3 | – | dephosphorylation down-regulates activity | 24726876 | SIGNOR-260944 | |
| TBK1 | IRF3 | – | phosphorylation up-regulates activity | 24622840 | SIGNOR-260154 | |
| ABL1 | IRF3 | Tyr292 | RLGHCHTyWAVSEEL | phosphorylation up-regulates activity | 30842273 | SIGNOR-277440 |
| TBK1 | IRF3 | – | phosphorylation up-regulates activity | 14679297 | SIGNOR-120355 | |
| DUSP10 | IRF3 | – | dephosphorylation down-regulates activity | 26305722 | SIGNOR-277146 | |
| IKBKE | IRF3 | Ser405 | SHPLSLTsDQYKAYL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178383 |
| PRKDC | IRF3 | Thr135 | GGGSTSDtQEDILDE | phosphorylation up-regulates | 11867762 | SIGNOR-115331 |
| PTEN | IRF3 | Ser97 | LRLAEDRsKDPHDPH | dephosphorylation up-regulates activity | 32394474 | SIGNOR-277025 |
| STK4 | IRF3 | Thr253 | PDPGMSLtDRGVMSY | phosphorylation up-regulates activity | 32174922 | SIGNOR-280144 |
| TBK1 | IRF3 | Ser402 | ISNSHPLsLTSDQYK | phosphorylation up-regulates activity | 18440553 | SIGNOR-178407 |
| IKBKE | IRF3 | Ser398 | VDLHISNsHPLSLTS | phosphorylation up-regulates activity | 18440553 | SIGNOR-178375 |
| TBK1 | IRF3 | Ser398 | VDLHISNsHPLSLTS | phosphorylation up-regulates activity | 18440553 | SIGNOR-178403 |
| STK4 | IRF3 | Thr75 | RDKPDLPtWKRNFRS | phosphorylation up-regulates activity | 32174922 | SIGNOR-280145 |
| IKBKE | IRF3 | Thr404 | NSHPLSLtSDQYKAY | phosphorylation up-regulates activity | 18440553 | SIGNOR-178387 |
| IKBKE | IRF3 | Ser402 | ISNSHPLsLTSDQYK | phosphorylation up-regulates activity | 18440553 | SIGNOR-178379 |
| MAPK8 | IRF3 | Ser173 | PCPQPLRsPSLDNPT | phosphorylation up-regulates | 19153595 | SIGNOR-183489 |
| TBK1 | IRF3 | Ser386 | ARVGGASsLENTVDL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178395 |
| ABL2 | IRF3 | Tyr292 | RLGHCHTyWAVSEEL | phosphorylation up-regulates activity | 30842273 | SIGNOR-277441 |
| SRC | IRF3 | Ser386 | ARVGGASsLENTVDL | phosphorylation up-regulates activity | 35468896 | SIGNOR-279119 |
| IKBKE | IRF3 | Ser385 | MARVGGAsSLENTVD | phosphorylation up-regulates activity | 18440553 | SIGNOR-178363 |
| GSK3B | IRF3 | – | phosphorylation up-regulates activity | 23685991 | SIGNOR-279182 | |
| SRC | IRF3 | Tyr107 | PHDPHKIyEFVNSGV | phosphorylation up-regulates activity | 35468896 | SIGNOR-279118 |
| IKBKE | IRF3 | Ser396 | NTVDLHIsNSHPLSL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178371 |
| TBK1 | IRF3 | Thr404 | NSHPLSLtSDQYKAY | phosphorylation up-regulates activity | 18440553 | SIGNOR-178420 |
| BGLF4 | IRF3 | Ser123 | DFSQPDTsPDTNGGG | phosphorylation down-regulates activity | 19052084 | SIGNOR-266647 |
| BGLF4 | IRF3 | Ser173 | PCPQPLRsPSLDNPT | phosphorylation down-regulates activity | 19052084 | SIGNOR-266648 |
| BGLF4 | IRF3 | Thr180 | SPSLDNPtPFPNLGP | phosphorylation down-regulates activity | 19052084 | SIGNOR-266649 |
| TBK1 | IRF3 | Ser385 | MARVGGAsSLENTVD | phosphorylation up-regulates activity | 18440553 | SIGNOR-178391 |
| TBK1 | IRF3 | Ser405 | SHPLSLTsDQYKAYL | phosphorylation up-regulates activity | 18440553 | SIGNOR-178411 |
| PPM1A | IRF3 | – | dephosphorylation down-regulates activity | 27419230 | SIGNOR-277152 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | phosphorylation up-regulates → | IRF3 PSer396 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178399 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer386 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178367 |
| ABL1 | phosphorylation up-regulates → | IRF3 PTyr292 | phosphorylation up-regulates → | IRF3 | 30842273 | SIGNOR-277440 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer405 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178383 |
| PRKDC | phosphorylation up-regulates → | IRF3 PThr135 | phosphorylation up-regulates → | IRF3 | 11867762 | SIGNOR-115331 |
| PTEN | dephosphorylation down-regulates ⊣ | IRF3 PSer97 | dephosphorylation down-regulates ⊣ | IRF3 | 32394474 | SIGNOR-277025 |
| STK4 | phosphorylation up-regulates → | IRF3 PThr253 | phosphorylation up-regulates → | IRF3 | 32174922 | SIGNOR-280144 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer402 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178407 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer398 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178375 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer398 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178403 |
| STK4 | phosphorylation up-regulates → | IRF3 PThr75 | phosphorylation up-regulates → | IRF3 | 32174922 | SIGNOR-280145 |
| IKBKE | phosphorylation up-regulates → | IRF3 PThr404 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178387 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer402 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178379 |
| MAPK8 | phosphorylation up-regulates → | IRF3 PSer173 | phosphorylation up-regulates → | IRF3 | 19153595 | SIGNOR-183489 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer386 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178395 |
| ABL2 | phosphorylation up-regulates → | IRF3 PTyr292 | phosphorylation up-regulates → | IRF3 | 30842273 | SIGNOR-277441 |
| SRC | phosphorylation up-regulates → | IRF3 PSer386 | phosphorylation up-regulates → | IRF3 | 35468896 | SIGNOR-279119 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer385 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178363 |
| SRC | phosphorylation up-regulates → | IRF3 PTyr107 | phosphorylation up-regulates → | IRF3 | 35468896 | SIGNOR-279118 |
| IKBKE | phosphorylation up-regulates → | IRF3 PSer396 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178371 |
| TBK1 | phosphorylation up-regulates → | IRF3 PThr404 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178420 |
| BGLF4 | phosphorylation up-regulates → | IRF3 PSer123 | phosphorylation down-regulates ⊣ | IRF3 | 19052084 | SIGNOR-266647 |
| BGLF4 | phosphorylation up-regulates → | IRF3 PSer173 | phosphorylation down-regulates ⊣ | IRF3 | 19052084 | SIGNOR-266648 |
| BGLF4 | phosphorylation up-regulates → | IRF3 PThr180 | phosphorylation down-regulates ⊣ | IRF3 | 19052084 | SIGNOR-266649 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer385 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178391 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer405 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178411 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178399 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178367 |
| PPP2CA | dephosphorylation → down-regulates activity | IRF3 | SIGNOR-260944 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-260154 |
| ABL1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-277440 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-120355 |
| DUSP10 | dephosphorylation → down-regulates activity | IRF3 | SIGNOR-277146 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178383 |
| PRKDC | phosphorylation → up-regulates | IRF3 | SIGNOR-115331 |
| PTEN | dephosphorylation → up-regulates activity | IRF3 | SIGNOR-277025 |
| STK4 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-280144 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178407 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178375 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178403 |
| STK4 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-280145 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178387 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178379 |
| MAPK8 | phosphorylation → up-regulates | IRF3 | SIGNOR-183489 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178395 |
| ABL2 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-277441 |
| SRC | phosphorylation → up-regulates activity | IRF3 | SIGNOR-279119 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178363 |
| GSK3B | phosphorylation → up-regulates activity | IRF3 | SIGNOR-279182 |
| SRC | phosphorylation → up-regulates activity | IRF3 | SIGNOR-279118 |
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178371 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178420 |
| BGLF4 | phosphorylation → down-regulates activity | IRF3 | SIGNOR-266647 |
| BGLF4 | phosphorylation → down-regulates activity | IRF3 | SIGNOR-266648 |
| BGLF4 | phosphorylation → down-regulates activity | IRF3 | SIGNOR-266649 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178391 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178411 |
| PPM1A | dephosphorylation → down-regulates activity | IRF3 | SIGNOR-277152 |
