| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | IRF3 | Tyr292 | RLGHCHTyWAVSEEL | phosphorylation up-regulates activity | 30842273 | SIGNOR-277440 |
| ABL2 | IRF3 | Tyr292 | RLGHCHTyWAVSEEL | phosphorylation up-regulates activity | 30842273 | SIGNOR-277441 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | IRF3 PTyr292 | phosphorylation up-regulates → | IRF3 | 30842273 | SIGNOR-277440 |
| ABL2 | phosphorylation up-regulates → | IRF3 PTyr292 | phosphorylation up-regulates → | IRF3 | 30842273 | SIGNOR-277441 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-277440 |
| ABL2 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-277441 |