| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKE | IRF3 | Ser398 | VDLHISNsHPLSLTS | phosphorylation up-regulates activity | 18440553 | SIGNOR-178375 |
| TBK1 | IRF3 | Ser398 | VDLHISNsHPLSLTS | phosphorylation up-regulates activity | 18440553 | SIGNOR-178403 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKE | phosphorylation up-regulates → | IRF3 PSer398 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178375 |
| TBK1 | phosphorylation up-regulates → | IRF3 PSer398 | phosphorylation up-regulates → | IRF3 | 18440553 | SIGNOR-178403 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKE | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178375 |
| TBK1 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-178403 |