| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | IRF3 | Ser173 | PCPQPLRsPSLDNPT | phosphorylation up-regulates | 19153595 | SIGNOR-183489 |
| BGLF4 | IRF3 | Ser173 | PCPQPLRsPSLDNPT | phosphorylation down-regulates activity | 19052084 | SIGNOR-266648 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | IRF3 PSer173 | phosphorylation up-regulates → | IRF3 | 19153595 | SIGNOR-183489 |
| BGLF4 | phosphorylation up-regulates → | IRF3 PSer173 | phosphorylation down-regulates ⊣ | IRF3 | 19052084 | SIGNOR-266648 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → up-regulates | IRF3 | SIGNOR-183489 |
| BGLF4 | phosphorylation → down-regulates activity | IRF3 | SIGNOR-266648 |
