| Name | MELK |
| ID | Q14680 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 11-263 PROSITE-ProRule
KA1 602-651 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MELK | PDPK1 | Thr354 | WENLHQQtPPKLTAY | phosphorylation down-regulates activity | 22544756 | SIGNOR-276414 |
| MELK | FOXO3 | – | phosphorylation down-regulates quantity | 28938528 | SIGNOR-279375 | |
| MELK | CDC25B | Ser219 | HALAEWAsRREAFAQ | phosphorylation down-regulates activity | 12400006 | SIGNOR-255655 |
| MELK | CDC25B | Ser169 | VLRNITNsQAPDGRR | phosphorylation up-regulates | 15908796 | SIGNOR-137378 |
| MELK | PTK2 | – | phosphorylation up-regulates activity | 24885567 | SIGNOR-279230 | |
| MELK | FOXM1 | – | phosphorylation up-regulates activity | 23404835 | SIGNOR-278412 | |
| MELK | FOXO1 | – | phosphorylation down-regulates quantity | 28938528 | SIGNOR-279543 | |
| MELK | SQSTM1 | – | phosphorylation up-regulates activity | 29212029 | SIGNOR-279544 | |
| MELK | MELK | Ser171 | HLQTCCGsLAYAAPE | phosphorylation up-regulates | 16216881 | SIGNOR-140958 |
| MELK | MELK | Ser356 | DIKSNNWsLEDVTAS | phosphorylation up-regulates | 16216881 | SIGNOR-140998 |
| MELK | MELK | Ser391 | GAATPRTsQFTKYWT | phosphorylation up-regulates | 16216881 | SIGNOR-141002 |
| MELK | MELK | Ser407 | SNGVESKsLTPALCR | phosphorylation up-regulates | 16216881 | SIGNOR-141006 |
| MELK | MELK | Ser431 | ENVYTPKsAVKNEEY | phosphorylation up-regulates | 16216881 | SIGNOR-141010 |
| MELK | MELK | Ser505 | SPERRCRsVELDLNQ | phosphorylation up-regulates | 16216881 | SIGNOR-141014 |
| MELK | MELK | Ser529 | KGAKVFGsLERGLDK | phosphorylation up-regulates | 16216881 | SIGNOR-141018 |
| MELK | MELK | Thr167 | NKDYHLQtCCGSLAY | phosphorylation up-regulates | 16216881 | SIGNOR-141022 |
| MELK | MELK | Thr398 | SQFTKYWtESNGVES | phosphorylation up-regulates | 16216881 | SIGNOR-141026 |
| MELK | MELK | Thr494 | TGTDKLMtGVISPER | phosphorylation up-regulates | 16216881 | SIGNOR-141030 |
| MELK | MELK | Thr539 | RGLDKVItVLTRSKR | phosphorylation up-regulates | 16216881 | SIGNOR-141034 |
| MELK | EZH2 | Ser220 | RPPRKFPsDKIFEAI | phosphorylation up-regulates quantity by stabilization | 31434700 | SIGNOR-277480 |
| MELK | MAP3K5 | – | phosphorylation up-regulates activity | 24185907 | SIGNOR-280039 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MELK | phosphorylation up-regulates → | PDPK1 PThr354 | phosphorylation down-regulates ⊣ | PDPK1 | 22544756 | SIGNOR-276414 |
| MELK | phosphorylation up-regulates → | CDC25B PSer219 | phosphorylation down-regulates ⊣ | CDC25B | 12400006 | SIGNOR-255655 |
| MELK | phosphorylation up-regulates → | CDC25B PSer169 | phosphorylation up-regulates → | CDC25B | 15908796 | SIGNOR-137378 |
| MELK | phosphorylation up-regulates → | MELK PSer171 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-140958 |
| MELK | phosphorylation up-regulates → | MELK PSer356 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-140998 |
| MELK | phosphorylation up-regulates → | MELK PSer391 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141002 |
| MELK | phosphorylation up-regulates → | MELK PSer407 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141006 |
| MELK | phosphorylation up-regulates → | MELK PSer431 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141010 |
| MELK | phosphorylation up-regulates → | MELK PSer505 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141014 |
| MELK | phosphorylation up-regulates → | MELK PSer529 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141018 |
| MELK | phosphorylation up-regulates → | MELK PThr167 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141022 |
| MELK | phosphorylation up-regulates → | MELK PThr398 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141026 |
| MELK | phosphorylation up-regulates → | MELK PThr494 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141030 |
| MELK | phosphorylation up-regulates → | MELK PThr539 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141034 |
| MELK | phosphorylation up-regulates → | EZH2 PSer220 | phosphorylation up-regulates → | EZH2 | 31434700 | SIGNOR-277480 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MELK | phosphorylation → down-regulates activity | PDPK1 | SIGNOR-276414 |
| MELK | phosphorylation → down-regulates quantity | FOXO3 | SIGNOR-279375 |
| MELK | phosphorylation → down-regulates activity | CDC25B | SIGNOR-255655 |
| MELK | phosphorylation → up-regulates | CDC25B | SIGNOR-137378 |
| MELK | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279230 |
| MELK | phosphorylation → up-regulates activity | FOXM1 | SIGNOR-278412 |
| MELK | phosphorylation → down-regulates quantity | FOXO1 | SIGNOR-279543 |
| MELK | phosphorylation → up-regulates activity | SQSTM1 | SIGNOR-279544 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-140958 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-140998 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141002 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141006 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141010 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141014 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141018 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141022 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141026 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141030 |
| MELK | phosphorylation → up-regulates | MELK | SIGNOR-141034 |
| MELK | phosphorylation → up-regulates quantity by stabilization | EZH2 | SIGNOR-277480 |
| MELK | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-280039 |