| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRA | KCNB1 | – | dephosphorylation down-regulates | 16870705 | SIGNOR-148301 | |
| PTPRE | KCNB1 | Tyr128 | YWGIDEIyLESCCQA | dephosphorylation down-regulates activity | 10921884 | SIGNOR-248450 |
| SRC | KCNB1 | Tyr128 | YWGIDEIyLESCCQA | phosphorylation up-regulates | 19622611 | SIGNOR-187201 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRE | dephosphorylation down-regulates ⊣ | KCNB1 PTyr128 | dephosphorylation up-regulates → | KCNB1 | 10921884 | SIGNOR-248450 |
| SRC | phosphorylation up-regulates → | KCNB1 PTyr128 | phosphorylation up-regulates → | KCNB1 | 19622611 | SIGNOR-187201 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRA | dephosphorylation down-regulates | KCNB1 | SIGNOR-148301 |
| PTPRE | dephosphorylation → down-regulates activity | KCNB1 | SIGNOR-248450 |
| SRC | phosphorylation → up-regulates | KCNB1 | SIGNOR-187201 |
