| Name | STAT4 |
| ID | Q14765 |
| Role | substrate |
| Enzymatic Domains |
SH2 569-664 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | STAT4 | Tyr693 | TERGDKGyVPSVFIP | phosphorylation up-regulates | 16324152 | SIGNOR-142736 |
| MAPK14 | STAT4 | Ser721 | PSDLLPMsPSVYAVL | phosphorylation up-regulates | 17502367 | SIGNOR-154787 |
| TYK2 | STAT4 | Tyr693 | TERGDKGyVPSVFIP | phosphorylation up-regulates activity | 16324152 | SIGNOR-279303 |
| MAP2K6 | STAT4 | Ser721 | PSDLLPMsPSVYAVL | phosphorylation up-regulates activity | 10961885 | SIGNOR-251425 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | STAT4 PTyr693 | phosphorylation up-regulates → | STAT4 | 16324152 | SIGNOR-142736 |
| MAPK14 | phosphorylation up-regulates → | STAT4 PSer721 | phosphorylation up-regulates → | STAT4 | 17502367 | SIGNOR-154787 |
| TYK2 | phosphorylation up-regulates → | STAT4 PTyr693 | phosphorylation up-regulates → | STAT4 | 16324152 | SIGNOR-279303 |
| MAP2K6 | phosphorylation up-regulates → | STAT4 PSer721 | phosphorylation up-regulates → | STAT4 | 10961885 | SIGNOR-251425 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates | STAT4 | SIGNOR-142736 |
| MAPK14 | phosphorylation → up-regulates | STAT4 | SIGNOR-154787 |
| TYK2 | phosphorylation → up-regulates activity | STAT4 | SIGNOR-279303 |
| MAP2K6 | phosphorylation → up-regulates activity | STAT4 | SIGNOR-251425 |