| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | KIF22 | Thr463 | QGAPLLStPKRERMV | phosphorylation up-regulates | 12727876 | SIGNOR-216793 |
| CDK1 | KIF22 | Thr463 | QGAPLLStPKRERMV | phosphorylation up-regulates activity | 12727876 | SIGNOR-100964 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | KIF22 PThr463 | phosphorylation up-regulates → | KIF22 | 12727876 | SIGNOR-216793 |
| CDK1 | phosphorylation up-regulates → | KIF22 PThr463 | phosphorylation up-regulates → | KIF22 | 12727876 | SIGNOR-100964 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → up-regulates | KIF22 | SIGNOR-216793 |
| CDK1 | phosphorylation → up-regulates activity | KIF22 | SIGNOR-100964 |
