| Name | LASP1 |
| ID | Q14847 |
| Role | substrate |
| Enzymatic Domains |
LIM zinc-binding 5-56 PROSITE-ProRule
SH3 202-261 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | LASP1 | Ser99 | KNKGKGFsVVADTPE | phosphorylation up-regulates activity | 12432067 | SIGNOR-250075 |
| ABL1 | LASP1 | Tyr171 | IPTSAPVyQQPQQQP | phosphorylation up-regulates | 15138294 | SIGNOR-124719 |
| SRC | LASP1 | Tyr171 | IPTSAPVyQQPQQQP | phosphorylation up-regulates activity | 19718473 | SIGNOR-271706 |
| PRKG1 | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12571245 | SIGNOR-97946 |
| BCR-ABL | LASP1 | Tyr171 | IPTSAPVyQQPQQQP | phosphorylation unknown | 24913448 | SIGNOR-271703 |
| PRKACA | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12571245 | SIGNOR-97938 |
| PRKCB | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12571245 | SIGNOR-97942 |
| PRKACA | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12432067 | SIGNOR-250074 |
| PRKG2 | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation unknown | 12571245 | SIGNOR-249197 |
| PRKACA | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 22665060 | SIGNOR-197720 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | LASP1 PSer99 | phosphorylation up-regulates → | LASP1 | 12432067 | SIGNOR-250075 |
| ABL1 | phosphorylation up-regulates → | LASP1 PTyr171 | phosphorylation up-regulates → | LASP1 | 15138294 | SIGNOR-124719 |
| SRC | phosphorylation up-regulates → | LASP1 PTyr171 | phosphorylation up-regulates → | LASP1 | 19718473 | SIGNOR-271706 |
| PRKG1 | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-97946 |
| BCR-ABL | phosphorylation up-regulates → | LASP1 PTyr171 | phosphorylation down-regulates ⊣ | LASP1 | 24913448 | SIGNOR-271703 |
| PRKACA | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-97938 |
| PRKCB | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-97942 |
| PRKACA | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12432067 | SIGNOR-250074 |
| PRKG2 | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-249197 |
| PRKACA | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 22665060 | SIGNOR-197720 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → up-regulates activity | LASP1 | SIGNOR-250075 |
| ABL1 | phosphorylation → up-regulates | LASP1 | SIGNOR-124719 |
| SRC | phosphorylation → up-regulates activity | LASP1 | SIGNOR-271706 |
| PRKG1 | phosphorylation → down-regulates activity | LASP1 | SIGNOR-97946 |
| BCR-ABL | phosphorylation → unknown | LASP1 | SIGNOR-271703 |
| PRKACA | phosphorylation → down-regulates activity | LASP1 | SIGNOR-97938 |
| PRKCB | phosphorylation → down-regulates activity | LASP1 | SIGNOR-97942 |
| PRKACA | phosphorylation → down-regulates activity | LASP1 | SIGNOR-250074 |
| PRKG2 | phosphorylation → unknown | LASP1 | SIGNOR-249197 |
| PRKACA | phosphorylation → down-regulates activity | LASP1 | SIGNOR-197720 |