| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 22665060 | SIGNOR-197720 |
| PRKG1 | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12571245 | SIGNOR-97946 |
| PRKACA | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12571245 | SIGNOR-97938 |
| PRKCB | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12571245 | SIGNOR-97942 |
| PRKACA | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12432067 | SIGNOR-250074 |
| PRKG2 | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation unknown | 12571245 | SIGNOR-249197 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 22665060 | SIGNOR-197720 |
| PRKG1 | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-97946 |
| PRKACA | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-97938 |
| PRKCB | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-97942 |
| PRKACA | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12432067 | SIGNOR-250074 |
| PRKG2 | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-249197 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | LASP1 | SIGNOR-197720 |
| PRKG1 | phosphorylation → down-regulates activity | LASP1 | SIGNOR-97946 |
| PRKACA | phosphorylation → down-regulates activity | LASP1 | SIGNOR-97938 |
| PRKCB | phosphorylation → down-regulates activity | LASP1 | SIGNOR-97942 |
| PRKACA | phosphorylation → down-regulates activity | LASP1 | SIGNOR-250074 |
| PRKG2 | phosphorylation → unknown | LASP1 | SIGNOR-249197 |
