| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | SLC9A5 | Ser709 | SEEEEEEsDSSETEK | phosphorylation down-regulates activity | 21296876 | SIGNOR-275504 |
| CSNK2A1 | SLC9A5 | Thr714 | EESDSSEtEKEDDEG | phosphorylation down-regulates activity | 21296876 | SIGNOR-276250 |
| GRK2 | SLC9A5 | Ser712 | EEEESDSsETEKEDD | phosphorylation down-regulates activity | 21296876 | SIGNOR-275500 |
| CSNK2A1 | SLC9A5 | Ser712 | EEEESDSsETEKEDD | phosphorylation down-regulates activity | 21296876 | SIGNOR-276249 |
| CSNK2A1 | SLC9A5 | Ser702 | AVILTVEsEEEEEES | phosphorylation down-regulates activity | 21296876 | SIGNOR-276253 |
| CSNK2A1 | SLC9A5 | Ser709 | SEEEEEEsDSSETEK | phosphorylation down-regulates activity | 21296876 | SIGNOR-276252 |
| CSNK2A1 | SLC9A5 | Ser711 | EEEEESDsSETEKED | phosphorylation down-regulates activity | 21296876 | SIGNOR-276251 |
| GRK2 | SLC9A5 | Ser711 | EEEEESDsSETEKED | phosphorylation down-regulates activity | 21296876 | SIGNOR-275501 |
| GRK2 | SLC9A5 | Ser702 | AVILTVEsEEEEEES | phosphorylation down-regulates activity | 21296876 | SIGNOR-275503 |
| GRK2 | SLC9A5 | Thr714 | EESDSSEtEKEDDEG | phosphorylation down-regulates activity | 21296876 | SIGNOR-275502 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | SLC9A5 PSer709 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275504 |
| CSNK2A1 | phosphorylation up-regulates → | SLC9A5 PThr714 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-276250 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PSer712 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275500 |
| CSNK2A1 | phosphorylation up-regulates → | SLC9A5 PSer712 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-276249 |
| CSNK2A1 | phosphorylation up-regulates → | SLC9A5 PSer702 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-276253 |
| CSNK2A1 | phosphorylation up-regulates → | SLC9A5 PSer709 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-276252 |
| CSNK2A1 | phosphorylation up-regulates → | SLC9A5 PSer711 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-276251 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PSer711 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275501 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PSer702 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275503 |
| GRK2 | phosphorylation up-regulates → | SLC9A5 PThr714 | phosphorylation down-regulates ⊣ | SLC9A5 | 21296876 | SIGNOR-275502 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275504 |
| CSNK2A1 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-276250 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275500 |
| CSNK2A1 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-276249 |
| CSNK2A1 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-276253 |
| CSNK2A1 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-276252 |
| CSNK2A1 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-276251 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275501 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275503 |
| GRK2 | phosphorylation → down-regulates activity | SLC9A5 | SIGNOR-275502 |
